Evidence map›Paper›PMID 30100715›Full record

ArticleInternational journal of chronic obstructive pulmonary disease2018

Identification of novel target genes in human lung tissue involved in chronic obstructive pulmonary disease.

Lena Heinbockel, Sebastian Marwitz, Andra B Schromm, Henrik Watz, Christian Kugler, Ole Ammerpohl, Karoline Schnepf, Klaus F Rabe, Daniel Droemann, Torsten Goldmann

Open access · goldAbstract read
In one paragraph

Article in International journal of chronic obstructive pulmonary disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. LKB1 deficiency upregulates RELM-α to drive airway goblet cell metaplasia.Cellular and molecular life sciences : CMLS · 2021
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Lena HeinbockelPathology of the University Medical Center Schleswig-Holstein (UKSH), Campus Luebeck and Research Center Borstel, Borstel, Germany, lheinbockel@fz-borstel.de.
Sebastian MarwitzPathology of the University Medical Center Schleswig-Holstein (UKSH), Campus Luebeck and Research Center Borstel, Borstel, Germany, lheinbockel@fz-borstel.de.
Andra B SchrommImmunobiophysics, Research Center Borstel, Borstel, Germany.
Henrik WatzAirway Research Center North (ARCN), German Center for Lung Research (DZL), Großhansdorf, Germany, lheinbockel@fz-borstel.de.
Christian KuglerAirway Research Center North (ARCN), German Center for Lung Research (DZL), Großhansdorf, Germany, lheinbockel@fz-borstel.de.
Ole AmmerpohlAirway Research Center North (ARCN), German Center for Lung Research (DZL), Großhansdorf, Germany, lheinbockel@fz-borstel.de.
Karoline SchnepfMedical Clinic III, Pulmonology/Infectious Diseases, University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Klaus F RabeAirway Research Center North (ARCN), German Center for Lung Research (DZL), Großhansdorf, Germany, lheinbockel@fz-borstel.de.
Daniel DroemannAirway Research Center North (ARCN), German Center for Lung Research (DZL), Großhansdorf, Germany, lheinbockel@fz-borstel.de.
Torsten GoldmannPathology of the University Medical Center Schleswig-Holstein (UKSH), Campus Luebeck and Research Center Borstel, Borstel, Germany, lheinbockel@fz-borstel.de.
German Center for Lung Research · DEUniversity Medical Center · USUniversity Hospital Schleswig-Holstein · DEResearch Center Borstel - Leibniz Lung Center · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: As part of a study aimed at illuminating at least some of the complex molecular events taking place in COPD, we screened tissues by means of transcriptome analyses. Materials and methods: Tissues were subjected to transcriptome analysis. Candidate genes were identified and validated by immunohistochemistry. Primary human lung cells were subjected to stimulation with cigarette smoke extract for further validation by real time PCR. Results: Six candidate genes were selected for further investigations: Aquaporin 3 ( Discussion:

Indexed as

Adaptor Proteins, Signal TransducingAgedAntigens, SurfaceAquaporin 3Cytoskeletal ProteinsDown-RegulationExtracellular Matrix ProteinsFemaleGene Expression ProfilingGermanyHumansIntracellular Signaling Peptides and ProteinsLIM Domain ProteinsLungMaleMilk ProteinsAdaptor Proteins, Signal TransducingAntigens, SurfaceAQP3 protein, humanAquaporin 3Cytoskeletal ProteinsECM1 protein, humanExtracellular Matrix ProteinsFHL1 protein, humanIntracellular Signaling Peptides and ProteinsLIM Domain ProteinsMFGE8 protein, humanMilk ProteinsMuscle ProteinsNerve Tissue ProteinsNuclear ProteinsPDE4DIP protein, humanPlasma Membrane Neurotransmitter Transport ProteinsSLC6A8 protein, humanSmokecigarette smoke extractCOPDCSEETS2MFGE8transcriptome

Identifiers

PMID30100715
PMCPMC6065552
OpenAlexW2884457702

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.