Evidence map›Paper›PMID 30100655›Full record

ArticleIndian journal of pharmacology

Pharmacokinetics and bioavailability of chromium malate and its influence on trace metals absorption after oral or intravenous administration.

Weiwei Feng, Qian Li, Wei Wang, Ting Zhao, Yun Feng, Fang Li, Guanghua Mao, Yao Chen, Yangyang Ding, Liuqing Yang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Weiwei FengDepartment of Environmental Engineering, School of the Environment and Safety Engineering, Institute of Environmental Health and Ecological Security, Jiangsu, China.
Qian LiDepartment of Food Science, School of Food and Biological Engineering, Jiangsu University, Jiangsu, China.
Wei WangDepartment of Food Science, School of Food and Biological Engineering, Jiangsu University, Jiangsu, China.
Ting ZhaoDepartment of Applied Chemistry, School of Chemistry and Chemical Engineering, Jiangsu University, Jiangsu, China.
Yun FengDepartment of Basic Medicine, School of Medical Science and Laboratory Medicine, Jiangsu University, Jiangsu, China.
Fang LiDepartment of Basic Medicine, School of Medical Science and Laboratory Medicine, Jiangsu University, Jiangsu, China.
Guanghua MaoDepartment of Environmental Engineering, School of the Environment and Safety Engineering, Institute of Environmental Health and Ecological Security, Jiangsu, China.
Yao ChenDepartment of Environmental Engineering, School of the Environment and Safety Engineering, Institute of Environmental Health and Ecological Security, Jiangsu, China.
Yangyang DingDepartment of Environmental Engineering, School of the Environment and Safety Engineering, Institute of Environmental Health and Ecological Security, Jiangsu, China.
Liuqing YangDepartment of Applied Chemistry, School of Chemistry and Chemical Engineering, Jiangsu University, Jiangsu, China.
Xiangyang WuDepartment of Environmental Engineering, School of the Environment and Safety Engineering, Institute of Environmental Health and Ecological Security, Jiangsu, China.
Jiangsu University · CNMinistry of Ecology and Environment · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIn our preliminary study, chromium malate could decrease the blood glucose level in mice with diabetes and exhibits good benefits in treating glycometabolism and adipose metabolization obstacle in rats with type 2 diabetes. This study was aimed at assessing the pharmacokinetics and bioavailability of chromium malate and influence on trace metals absorption in rats.

methodsBAPP 2.3 pharmacokinetic calculating program (China Pharmaceutical University Medicine Center) was used to calculate the pharmacokinetic parameters. Models of type 2 diabetic mellitus rats were applied to analyzed Ca, Mg, Fe, Cu, and Zn contents.

resultsThe results showed that mean retention time (MRT) in chromium malate group was significantly prolonged and the area under the curve (AUC) and relative bioavailability of chromium malate (male) group were significant increase compared to chromium picolinate group. The serum Ca, Mg, Fe, Cu, and Zn contents in chromium malate (at doses of 15 and 20 μg Cr/kg bw) groups were significantly increased compared to control group, chromium trichloride group, and chromium picolinate group in type 2 diabetes mellitus rats.

conclusionsThose results indicated that chromium malate can significantly prolong MRT and increase AUC (male). Moreover, chromium malate is more effective at treating increased serum Ca, Mg, Fe, Cu, and Zn contents compared to chromium trichloride and chromium picolinate.

Indexed as

Administration, IntravenousAdministration, OralAnimalsBiological AvailabilityChloridesChromium CompoundsDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2FecesFemaleMalatesMaleMetalsPicolinic AcidsRatsRats, Sprague-DawleyChlorideschromic chlorideChromium CompoundsMalatesMetalspicolinic acidPicolinic AcidsBioavailabilitychromiumchromium malatechromium picolinatepharmacokinetic

Identifiers

PMID30100655
PMCPMC6044135
OpenAlexW2855417218

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.