Genomic sequencing in acutely ill infants: what will it take to demonstrate clinical value?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

10 citing papers in PubMed.

1. An RCT of Rapid Genomic Sequencing among Seriously Ill Infants Results in High Clinical Utility, Changes in Management, and Low Perceived Harm.American journal of human genetics · 2020
   Trial
2. Next-Generation Whole-Exome Pattern: Advanced Methods and Clinical Significance.Current gene therapy · 2026
   Review
3. 3-hour genome sequencing and targeted analysis to rapidly assess genetic risk.Genetics in medicine open · 2024
   Article
4. Positioning whole exome sequencing in the diagnostic pathway for rare disease to optimise utility: a protocol for an observational cohort study and an economic evaluation.BMJ open · 2022
   Article
5. Perspectives of United States neonatologists on genetic testing practices.Genetics in medicine : official journal of the American College of Medical Genetics · 2022
   Article
6. The IDeaS initiative: pilot study to assess the impact of rare diseases on patients and healthcare systems.Orphanet journal of rare diseases · 2021
   Article
7. Cost Efficacy of Rapid Whole Genome Sequencing in the Pediatric Intensive Care Unit.Frontiers in pediatrics · 2021
   Article
8. Clinical utility of genomic sequencing: a measurement toolkit.NPJ genomic medicine · 2020
   Review
9. Feasibility of Ultra-Rapid Exome Sequencing in Critically Ill Infants and Children With Suspected Monogenic Conditions in the Australian Public Health Care System.JAMA · 2020
   Article
10. Rapid Whole Genome Sequencing Has Clinical Utility in Children in the PICU.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2019
    Article

Corrections and comments

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  Genome-wide sequencing in acutely ill infants: genomic medicine's critical application?2019

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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