Evidence map›Paper›PMID 30100544›Full record

ArticleThe journal of international advanced otology2018

Association between Uncoupling Protein 2 Gene Ala55val Polymorphism and Sudden Sensorineural Hearing Loss.

Yusuke Koide, Masaaki Teranishi, Saiko Sugiura, Yasue Uchida, Naoki Nishio, Ken Kato, Hironao Otake, Tadao Yoshida, Rei Otsuka, Fujiko Ando and 4 more

Open access · diamondAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of international advanced otology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Yusuke KoideDepartment of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Masaaki TeranishiDepartment of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Saiko SugiuraToyota Josui Mental Clinic, Aichi, Japan; Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Aichi, Japan.
Yasue UchidaDepartment of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Aichi, Japan; Department of Otorhinolaryngology, Aichi Medical University School of Medicine, Aichi, Japan.
Naoki NishioDepartment of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Ken KatoDepartment of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hironao OtakeDepartment of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Tadao YoshidaDepartment of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Rei OtsukaSection of National Institute for Longevity Sciences, Longitudinal Study of Aging Aichi, Japan.
Fujiko AndoSection of National Institute for Longevity Sciences, Longitudinal Study of Aging (NISL-LSA), National Center for Geriatrics and Gerontology, Aichi, Japan.
Hiroshi ShimokataGraduate School of Nutritional Sciences, Nagoya University of Arts and Sciences, Aichi, Japan; Section of National Institute for Longevity Sciences, Longitudinal Study of Aging Aichi, Japan.
Yasuhisa HasegawaDepartment of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
Tsutomu NakashimaIchinomiya Medical Treatment and Habilitation Center, Aichi, Japan.
Michihiko SoneDepartment of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Nagoya University · JPNational Center for Geriatrics and Gerontology · JPAichi Cancer Center · JPAichi Medical University · JPIchinomiya Kenshin College · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe pathology of sudden sensorineural hearing loss, which is known as sudden deafness (SD), remains unknown. The purpose of this study was to investigate the association between mitochondrial uncoupling protein 2 (UCP2) polymorphism and SD risk. MATERIALS AND

methodsWe compared 83 patients suffering from SD and 2048 controls who participated in the Longitudinal Study of Aging at the National Institute for Longevity Sciences. Multiple logistic regression was used to calculate the odds ratios (ORs) for SD with a polymorphism of the UCP2 (rs660339) gene.

resultsUnder the additive model of inheritance, UCP2 polymorphisms showed significant association with a SD risk. The OR was 1.468 (95% confidence interval, 1.056-2.040) with an adjustment for any past history, such as diabetes, dyslipidemia, or hypertension, and for age and sex.

conclusionOur results imply that the UCP2 (rs660339) polymorphism has a significant association with the risk of developing SD.

Indexed as

AdultAgedCase-Control StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHearing Loss, SensorineuralHearing Loss, SuddenHumansJapanMaleMiddle AgedPolymorphism, GeneticRetrospective StudiesRisk FactorsUncoupling Protein 2

Identifiers

PMID30100544
PMCPMC6354460
OpenAlexW2887337377

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.