ArticleCurrent biology : CB2018
Phase-Locked Stimulation during Cortical Beta Oscillations Produces Bidirectional Synaptic Plasticity in Awake Monkeys.
Article in Current biology : CB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- Characterising motor and cognitive contributions of cortical beta oscillations and their modulation with rTMS.NeuroImage · 2026Article
- Optimizing real-time phase detection in diverse rhythmic biological signals for phase-specific neurostimulation.Journal of neural engineering · 2025Article
- Flexible modeling of large-scale neural network stimulation: Electrical and optical extensions to The Virtual Electrode Recording Tool for EXtracellular Potentials (VERTEX).Journal of neuroscience methods · 2025Article
- Gamma-band synchronization between neurons in the visual cortex is causal for effective information processing and behavior.Nature communications · 2025Article
- Frontal midline theta power accounts for inter-individual differences in motor learning ability.Experimental brain research · 2025Article
- Closed-loop control of theta oscillations enhances human hippocampal network connectivity.Nature communications · 2025Article
- Flexible modeling of large-scale neural network stimulation: electrical and optical extensions to The Virtual Electrode Recording Tool for EXtracellular Potentials (VERTEX).bioRxiv : the preprint server for biology · 2025Article
- Real-time TMS-EEG for brain state-controlled research and precision treatment: a narrative review and guide.Journal of neural engineering · 2024Review
- Article
- Low and high beta rhythms have different motor cortical sources and distinct roles in movement control and spatiotemporal attention.PLoS biology · 2024Article
- NSF DARE-Transforming modeling in neurorehabilitation: Four threads for catalyzing progress.Journal of neuroengineering and rehabilitation · 2024Review
- Novel Cyclic Homogeneous Oscillation Detection Method for High Accuracy and Specific Characterization of Neural Dynamics.bioRxiv : the preprint server for biology · 2024Article
- Development and Evaluation of a Real-Time Phase-Triggered Stimulation Algorithm for the CorTec Brain Interchange.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2024Article
- Distinct Olfactory Bulb-Cortex Neural Circuits Coordinate Cognitive Function in Parkinson's Disease.Research (Washington, D.C.) · 2024Article
- Closing the loop in psychiatric deep brain stimulation: physiology, psychometrics, and plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Scalable, flexible carbon fiber electrode thread arrays for three-dimensional probing of neurochemical activity in deep brain structures of rodents.Biosensors & bioelectronics · 2023Article
- Open Mind Neuromodulation Interface for the CorTec Brain Interchange (OMNI-BIC): an investigational distributed research platform for next-generation clinical neuromodulation research.International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering · 2023Article
- Closed-loop optogenetic control of the dynamics of neural activity in non-human primates.Nature biomedical engineering · 2023Article
- Article
- Stable, interactive modulation of neuronal oscillations produced through brain-machine equilibrium.Cell reports · 2022Article
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Abstract
The functional role of cortical beta oscillations, if any, remains unresolved. During oscillations, the periodic fluctuation in excitability of entrained cells modulates transmission of neural impulses and periodically enhances synaptic interactions. The extent to which oscillatory episodes affect activity-dependent synaptic plasticity remains to be determined. In nonhuman primates, we delivered single-pulse electrical cortical stimulation to a "stimulated" site in sensorimotor cortex triggered on a specific phase of ongoing beta (12-25 Hz) field potential oscillations recorded at a separate "triggering" site. Corticocortical connectivity from the stimulated to the triggering site as well as to other (non-triggering) sites was assessed by cortically evoked potentials elicited by test stimuli to the stimulated site, delivered outside of oscillatory episodes. In separate experiments, connectivity was assessed by intracellular recordings of evoked excitatory postsynaptic potentials. The conditioning paradigm produced transient (1-2 s long) changes in connectivity between the stimulated and the triggering site that outlasted the duration of the oscillatory episodes. The direction of the plasticity effect depended on the phase from which stimulation was triggered: potentiation in depolarizing phases, depression in hyperpolarizing phases. Plasticity effects were also seen at non-triggering sites that exhibited oscillations synchronized with those at the triggering site. These findings indicate that cortical beta oscillations provide a spatial and temporal substrate for short-term, activity-dependent synaptic plasticity in primate neocortex and may help explain the role of oscillations in attention, learning, and cortical reorganization.
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