Evidence map›Paper›PMID 30100196›Full record

ArticleCell metabolism2018

Circulating Adipose Fatty Acid Binding Protein Is a New Link Underlying Obesity-Associated Breast/Mammary Tumor Development.

Jiaqing Hao, Yuwen Zhang, Xiaofang Yan, Fei Yan, Yanwen Sun, Jun Zeng, Sabine Waigel, Yanhui Yin, Mostafa M Fraig, Nejat K Egilmez and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 1 synthesis or guideline pooled it, 158 citations in OpenAlex.

  1. Pooled it
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  14. Murine Models of Obesity-Related Cancer Risk.Cancer prevention research (Philadelphia, Pa.) · 2025
    Review
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  17. Article
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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Jiaqing HaoDepartment of Microbiology and Immunology, University of Louisville, 505 South Hancock Street, Louisville, KY 40202, USA.
Yuwen ZhangDepartment of Microbiology and Immunology, University of Louisville, 505 South Hancock Street, Louisville, KY 40202, USA.
Xiaofang YanDepartment of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY, USA.
Fei YanThe Hormel Institute, University of Minnesota, Austin, MN, USA.
Yanwen SunDepartment of Microbiology and Immunology, University of Louisville, 505 South Hancock Street, Louisville, KY 40202, USA.
Jun ZengDepartment of Microbiology and Immunology, University of Louisville, 505 South Hancock Street, Louisville, KY 40202, USA; School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
Sabine WaigelGenomics Facility and Life Tech Supply Center, University of Louisville, Louisville, KY, USA.
Yanhui YinDepartment of Immunology, Peking University Health Science Center, Beijing, China.
Mostafa M FraigDepartment of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY, USA.
Nejat K EgilmezDepartment of Microbiology and Immunology, University of Louisville, 505 South Hancock Street, Louisville, KY 40202, USA.
Jill SuttlesDepartment of Microbiology and Immunology, University of Louisville, 505 South Hancock Street, Louisville, KY 40202, USA.
Maiying KongDepartment of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY, USA.
Shujun LiuThe Hormel Institute, University of Minnesota, Austin, MN, USA.
Margot P ClearyThe Hormel Institute, University of Minnesota, Austin, MN, USA.
Edward SauterHartford Healthcare Cancer Institute, Hartford, CT, USA.
Bing LiDepartment of Microbiology and Immunology, University of Louisville, 505 South Hancock Street, Louisville, KY 40202, USA. Electronic address: b.li@louisville.edu.
University of Louisville · USUniversity of Minnesota · USHartford Hospital · USPeking University · CN

Funding

WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1M
PILOT PROJECT PROGRAMP30GM106396 · NIGMS · UNIVERSITY OF LOUISVILLE · PI EATON, JOHN W · 2013 to 2017
$5.4M
Prevention of Breast Cancer Development by Epidermal Fatty Acid Binding Protein (R01CA180986 · NCI · UNIVERSITY OF MINNESOTA · PI LI, BING · 2014 to 2025
$3.3M
The role of adipocyte/macrophage fatty acid binding protein in breast cancer deveR01CA177679 · NCI · UNIVERSITY OF MINNESOTA · PI LI, BING · 2014 to 2018
$1.6M
NCI NIH HHS R01 CA177679NCI NIH HHS R01 CA180986NIGMS NIH HHS P20 GM103436NIGMS NIH HHS P30 GM106396
6 · The paper itself

Abstract

It is clear that obesity increases the risk of many types of cancer, including breast cancer. However, the underlying molecular mechanisms by which obesity is linked to cancer risk remain to be defined. Herein, we report that circulating adipose fatty acid binding protein (A-FABP) promotes obesity-associated breast cancer development. Using clinical samples, we demonstrated that circulating A-FABP levels were significantly increased in obese patients with breast cancer in comparison with those without breast cancer. Circulating A-FABP released by adipose tissue directly targeted mammary tumor cells, enhancing tumor stemness and aggressiveness through activation of the IL-6/STAT3/ALDH1 pathway. Importantly, genetic deletion of A-FABP successfully reduced tumor ALHD1 activation and obesity-associated mammary tumor growth and development in different mouse models. Collectively, these data suggest circulating A-FABP as a new link between obesity and breast cancer risk, thereby revealing A-FABP as a potential new therapeutic target for treatment of obesity-associated cancers.

Indexed as

Aldehyde Dehydrogenase 1 FamilyAnimalsBiomarkers, TumorBreast NeoplasmsDisease Models, AnimalDisease ProgressionFatty Acid-Binding ProteinsFemaleHumansInterleukin-6IsoenzymesMice, Inbred C57BLNeoplasm InvasivenessObesityRetinal DehydrogenaseSignal TransductionAldehyde Dehydrogenase 1 FamilyALDH1A1 protein, humanALDH1A1 protein, mouseBiomarkers, TumorFABP4 protein, humanFabp4 protein, mouseFatty Acid-Binding ProteinsInterleukin-6IsoenzymesRetinal DehydrogenaseSTAT3 Transcription FactorA-FABPbreast cancer developmentobesitytumor stemness

Identifiers

PMID30100196
PMCPMC6221972
OpenAlexW2886026800

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.