Evidence map›Paper›PMID 30100167›Full record

ArticleCell stem cell2018

Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration.

Heather A Himburg, Christina M Termini, Lauren Schlussel, Jenny Kan, Michelle Li, Liman Zhao, Tiancheng Fang, Joshua P Sasine, Vivian Y Chang, John P Chute

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 132 citations in OpenAlex.

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  17. Deep imaging of LepRBone research · 2025
    Article
  18. Article
  19. Effect of bone marrow niche on hematopoietic stem cells.Histochemistry and cell biology · 2024
    Review
  20. Review

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Heather A HimburgDivision of Hematology/Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Christina M TerminiDivision of Hematology/Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Lauren SchlusselDivision of Hematology/Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jenny KanDivision of Hematology/Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Michelle LiDivision of Hematology/Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Liman ZhaoDivision of Hematology/Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Tiancheng FangDivision of Hematology/Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Joshua P SasineDivision of Hematology/Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Molecular, Cellular and Integrative Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Vivian Y ChangDivision of Pediatric Hematology/Oncology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Children's Discovery and Innovation Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.
John P ChuteDivision of Hematology/Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Broad Stem Cell Research Center, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: jchute@mednet.ucla.edu.
University of California, Los Angeles · USBroad Center · US

Funding

UCLA Center for Biological RadioprotectorsU19AI067769 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHUTE, JOHN P, MCBRIDE, WILLIAM H. · 2005 to 2019
$44.6M
Semaphorin signaling regulates vascular and hematopoietic regenerationR01HL086998 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHUTE, JOHN P · 2008 to 2022
$4.6M
Dkk1-Endothelial Progenitor Cell Treatment for the Mitigation of Hematopoietic Radiation InjuryU01AI138331 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HIMBURG, HEATHER A · 2018 to 2022
$3.0M
Epidermal growth factor mitigates radiation-induced hematopoietic failureU01AI107333 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHUTE, JOHN P · 2013 to 2017
$2.6M
Regulation of Stem Cell Aging and Cancer by the Vascular NicheK08HL138305 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHANG, VIVIAN Y-J · 2017 to 2021
$891k
NHLBI NIH HHS K08 HL138305NHLBI NIH HHS R01 HL086998NIAID NIH HHS U01 AI107333NIAID NIH HHS U01 AI138331NIAID NIH HHS U19 AI067769
6 · The paper itself

Abstract

Bone marrow (BM) perivascular stromal cells and vascular endothelial cells (ECs) are essential for hematopoietic stem cell (HSC) maintenance, but the roles of distinct niche compartments during HSC regeneration are less understood. Here we show that Leptin receptor-expressing (LepR+) BM stromal cells and ECs dichotomously regulate HSC maintenance and regeneration via secretion of pleiotrophin (PTN). BM stromal cells are the key source of PTN during steady-state hematopoiesis because its deletion from stromal cells, but not hematopoietic cells, osteoblasts, or ECs, depletes the HSC pool. Following myelosuppressive irradiation, PTN expression is increased in bone marrow endothelial cells (BMECs), and PTN

Indexed as

Cell Self RenewalAnimalsBone MarrowCarrier ProteinsCytokinesFemaleHematopoietic Stem CellsMaleMiceMice, Inbred C57BLCarrier ProteinsCytokinespleiotrophinendothelial cellshematopoiesismicroenvironmentnichepleiotrophinregenerationself-renewalstem cells

Identifiers

PMID30100167
PMCPMC6482945
OpenAlexW2886889723

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.