Trial reportClinical nutrition (Edinburgh, Scotland)2019
Preserved anabolic threshold and capacity as estimated by a novel stable tracer approach suggests no anabolic resistance or increased requirements in weight stable COPD patients.
Trial report in Clinical nutrition (Edinburgh, Scotland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01734473 (Casein Protein and Leucine Supplementation to Induce Anabolism in COPD Patients and Healthy Elderly), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Casein Protein and Leucine Supplementation to Induce Anabolism in COPD Patients and Healthy Elderly
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Guideline
- ω-3 polyunsaturated fatty acid supplementation improves postabsorptive and prandial protein metabolism in patients with chronic obstructive pulmonary disease: a randomized clinical trial.The American journal of clinical nutrition · 2022Trial
- Advances in nutritional metabolic therapy to impede the progression of critical illness.Frontiers in nutrition · 2024Review
- Compartmental analysis: a new approach to estimate protein breakdown and meal response in health and critical illness.Frontiers in nutrition · 2024Review
- Efficacy of interventions to alter measures of fat-free mass in people with COPD: a systematic review and meta-analysis.ERJ open research · 2023Review
- Intestinal function is impaired in patients with Chronic Obstructive Pulmonary Disease.Clinical nutrition (Edinburgh, Scotland) · 2021Observational
- Activated whole-body arginine pathway in high-active mice.PloS one · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
BACKGROUND &
aimsAssessing the ability to respond anabolic to dietary protein intake during illness provides important insight in the capacity of lean body mass maintenance. We applied a newly developed stable tracer approach to assess in one session in patients with chronic obstructive pulmonary disease (COPD) and healthy older adults both the minimal amount of protein intake to obtain protein anabolism (anabolic threshold) and the efficiency of dietary protein to promote protein anabolism (anabolic capacity).
methodsWe studied 12 clinically and weight stable patients with moderate to very severe COPD (mean ± SE forced expiratory volume in 1 s: 36 ± 3% of predicted) and 10 healthy age-matched older adults. At 2-h intervals and in consecutive order, all participants consumed a mixture of 0.0, 0.04, 0.10 and 0.30 g hydrolyzed casein protein×kg ffm
resultsWe confirmed a linear relationship between protein intake and net protein balance for all participants (R
conclusionsThe preserved anabolic threshold and capacity in clinically and weight stable COPD patients suggests no disease related anabolic resistance and/or increased protein requirements. TRIAL REGISTRY: ClinicalTrials.gov; No. NCT01734473; URL: www.clinicaltrials.gov.
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