ArticleThe Journal of surgical research2018
Impaired coronary contraction to phenylephrine after cardioplegic arrest in diabetic patients.
Article in The Journal of surgical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Uncontrolled hypertension contributes to vascular permeability after cardioplegic arrest and cardiopulmonary bypass.JTCVS open · 2026Article
- Increased Coronary Contraction to Thromboxane A2 in Cardiac Surgery Patients With Poorly Controlled Hypertension.The Journal of surgical research · 2024Article
- Poorly controlled hypertension is associated with increased coronary myogenic tone in patients undergoing cardiac surgery with cardiopulmonary bypass.The Journal of thoracic and cardiovascular surgery · 2023Article
- Article
- Cardioprotective effect of hyperkalemic cardioplegia in an aquaporin 7-deficient murine heart.General thoracic and cardiovascular surgery · 2020Article
- Skeletal muscle microvasculature response to β-adrenergic stimuli is diminished with cardiac surgery.Surgery · 2020Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWe have previously found that hyperkalemic cardioplegic arrest in the setting of cardiopulmonary bypass (CP/CPB) is associated with impairment of the coronary arteriolar response to phenylephrine in nondiabetic (ND) patients. We hypothesized that diabetes may alter coronary arteriolar response to alpha-1 adrenergic agonist in the setting of CP/CPB. In this study, we further investigated the effects of diabetes on the altered coronary arteriolar response to phenylephrine in patients undergoing cardiac surgery.
methodsCoronary arterioles (90-150 μm in diameter) were harvested pre- and post-CP/CPB from the ND and diabetic mellitus (DM) patients (n = 8/group) undergoing cardiac surgery. In-vitro microvascular reactivity was examined in response to phenylephrine. The protein expression/localization of the alpha-1 adrenergic receptors in the atrial myocardium was measured by Western blotting and immunohistochemistry.
resultsPhenylephrine (10
conclusionsDiabetes is associated with a decreased contractile response of coronary arterioles to phenylephrine in the setting of CP/CPB versus that observed in ND patients. This alteration may contribute to the vasomotor dysfunction of coronary microcirculation seen early after CP/CPB in patients with diabetes.
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