ArticleJournal of diabetes and its complications2018
Differential relationship between colorectal cancer and diabetes in a nationally representative sample of adults.
Article in Journal of diabetes and its complications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Effect of type 2 diabetes mellitus on systemic treatment for advanced non-small cell lung cancer.Translational lung cancer research · 2025Article
- Long-term survival analysis of patients with stage IIIB-IV non-small cell lung cancer complicated by type 2 diabetes mellitus: A retrospective propensity score matching analysis.Thoracic cancer · 2022Article
- Glucose Intolerance and Cancer Risk: A Community-Based Prospective Cohort Study in Shanghai, China.Frontiers in oncology · 2021Article
- Obesity, diabetes and the risk of colorectal adenoma and cancer.BMC endocrine disorders · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDiabetes has been identified as a risk factor for developing colorectal cancer (CRC); however, the literature identifying groups most at risk is sparse. This study aims to understand the relationship between CRC and diabetes by age and race/ethnicity.
methodsThis is a cross-sectional study of data from the 2001-2014 National Health and Nutrition Examination Survey (unweighted n = 37,173; weighted n = 214,363,348). Individuals were categorized as having CRC if diagnosed with colon or rectal cancer and as having diabetes if told by a doctor they had diabetes, were taking insulin, or had an HbA1c ≥ 6.5%. Covariates included gender, age, race, marital status, educational level and income as a ratio of the poverty line. Multivariable logistic regression was used to assess the relationship between CRC and diabetes overall and stratified by age and by race.
results24.32% of the sample with CRC also had diabetes. After adjusting for covariates, individuals with diabetes had a 47% greater probability of having CRC (p = 0.03). While significance did not persist after stratification for those ≥65 years (OR = 1.06, p = 0.74), those <65 years with diabetes had nearly 5-times higher odds of having CRC (OR = 4.78, p < 0.001). When stratified by race, both groups had statistically higher odds of having CRC; however, the odds for non-whites (OR = 1.87, p = 0.04) were higher compared to whites (OR = 1.54, p = 0.03).
conclusionIndividuals younger than 65 and racial/ethnic minorities have higher odds of CRC when also diagnosed with diabetes. Targeted interventions for these populations, especially regarding screening recommendations, may result in earlier detection of CRC and improved health outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.