Evidence map›Paper›PMID 30099859›Full record

Trial reportArthritis care & research2019

Decreased Pain and Improved Dynamic Knee Instability Mediate the Beneficial Effect of Wearing a Soft Knee Brace on Activity Limitations in Patients With Knee Osteoarthritis.

Tomasz Cudejko, Martin van der Esch, Josien C van den Noort, Judith J M Rijnhart, Marike van der Leeden, Leo D Roorda, Willem Lems, Gordon Waddington, Jaap Harlaar, Joost Dekker

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Arthritis care & research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. The effectiveness of knee bracing in non-operative soft tissue and degenerative knee injuries: A systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Tomasz CudejkoVU Medical Center, Amsterdam Movement Sciences and Amsterdam Rehabilitation Research Center Reade, Amsterdam, The Netherlands.
Martin van der EschAmsterdam Rehabilitation Research Center Reade, Amsterdam, The Netherlands.
Josien C van den NoortVU Medical Center, Amsterdam Movement Sciences and Musculoskeletal Imaging Quantification Center, Academic Medical Center, Amsterdam, The Netherlands.
Judith J M RijnhartVU University Medical Center, Amsterdam, The Netherlands.
Marike van der LeedenVU Medical Center, Amsterdam Movement Sciences and Amsterdam Rehabilitation Research Center Reade, Amsterdam, The Netherlands.
Leo D RoordaAmsterdam Rehabilitation Research Center Reade, Amsterdam, The Netherlands.
Willem LemsJan van Breemen Research Institute, Reade and Amsterdam Rheumatology and Immunology Centre, Amsterdam, The Netherlands.
Gordon WaddingtonResearch Institute for Sport and Exercise, University of Canberra, Canberra, Australia.
Jaap HarlaarVU University Medical Center, Amsterdam Movement Sciences and Amsterdam and Delft University of Technology, Delft, The Netherlands.
Joost DekkerVU Medical Center, Amsterdam Movement Sciences and VU University Medical Center, Amsterdam, The Netherlands.
Amsterdam UMC Location VUmc · NLReade · NLDelft University of Technology · NLUniversity of Canberra · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate whether improvement of proprioception, pain, or dynamic knee instability mediates the effect of wearing a soft knee brace on activity limitations in patients with knee osteoarthritis (OA).

methodsWe conducted an analysis of data for 44 patients with knee OA who were enrolled in a laboratory-based trial evaluating the effect of wearing a commercially available soft knee brace. Activity limitations were assessed with the 10-meter walk test and the Get Up and Go test. Knee joint proprioception was assessed by an active joint position sense test; pain was assessed on a numeric rating scale (NRS) (range 0-10); pressure pain threshold (PPT) was assessed with a hand-held pressure algometer; dynamic knee instability was expressed by the perturbation response, i.e., a measure reflecting a deviation in mean knee varus-valgus angle after a controlled mechanical perturbation on a treadmill, with respect to level walking. Mediation analysis was conducted using the product of coefficients approach. Confidence intervals were calculated with a bootstrap procedure.

resultsA decrease in pain (scored on an NRS) and a decrease in dynamic knee instability mediated the effect of wearing a soft knee brace on the reduction of activity limitations (P < 0.05), while changes in proprioception and PPT did not mediate this effect (P > 0.05).

conclusionThis study shows that decreased pain and reduced dynamic knee instability are pathways by which wearing a soft knee brace decreases activity limitations in patients with knee OA.

Indexed as

BracesAgedFemaleHumansJoint InstabilityKnee JointMaleMiddle AgedOsteoarthritis, KneePainProprioception

Identifiers

PMID30099859
PMCPMC6771793
OpenAlexW2885528338

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.