Evidence map›Paper›PMID 30099853›Full record

ArticleJournal of diabetes investigation2019

Verification of Kumamoto Declaration 2013 and Glycemic Targets for Elderly Patients with Diabetes in Japan for prevention of diabetic complications: A retrospective longitudinal study using outpatient clinical data.

Shuhei Nakanishi, Hidenori Hirukawa, Masashi Shimoda, Fuminori Tatsumi, Kenji Kohara, Atsushi Obata, Tomohiko Kimura, Seizo Okauchi, Tomoe Kinoshita, Junpei Sanada and 6 more

Abstract read
In one paragraph

Article in Journal of diabetes investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shuhei NakanishiDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.ORCID http://orcid.org/0000-0003-2640-9632
Hidenori HirukawaDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.ORCID http://orcid.org/0000-0002-4826-2574
Masashi ShimodaDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.
Fuminori TatsumiDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.
Kenji KoharaDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.
Atsushi ObataDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.
Tomohiko KimuraDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.ORCID http://orcid.org/0000-0003-3986-9494
Seizo OkauchiDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.
Tomoe KinoshitaDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.
Junpei SanadaDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.
Yoshiro FushimiDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.
Momoyo NishiokaDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.
Akiko MizoguchiDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.
Tomoatsu MuneDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.
Kohei KakuDepartment of General Internal Medicine 1, Kawasaki Hospital, Kawasaki Medical School, Okayama, Japan.
Hideaki KanetoDivision of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan.ORCID http://orcid.org/0000-0001-7898-1943

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AIMS/

introductionThe present study examined the association between the onset of micro- and macroangiopathy in type 2 diabetes mellitus patients and levels of glycated hemoglobin (HbA1c) described in the Evidence-based Practice Guideline for the Treatment for Diabetes in Japan 2013 or those indicated in the Japan Diabetes Society and the Japan Geriatrics Society Joint Committee on Improving Care for Elderly Patients with Diabetes. MATERIALS AND

methodsPatients with type 2 diabetes mellitus who visited the outpatient clinic at Kawasaki Medical School Hospital between 2000 and 2016 and received follow up for >2 years were eligible for the present study. Two datasets, comprising 2,424 or 3,316 patients without micro- or macroangiopathy at the start of follow up, were used, respectively. The Cox model was used in two categories of patients, younger and elderly, with the dividing line set at the age of 65 years.

resultsFor the prevention of microangiopathy, in all patients, there was found to be no advantage in controlling HbA1c at a level of <6.0% based on the categories in the Evidence-based Practice Guideline for the Treatment for Diabetes in Japan 2013, and there was found to be a disadvantage in maintaining HbA1c ≥8.5% based on the categories in the Japan Diabetes Society and the Japan Geriatrics Society Joint Committee on Improving Care for Elderly Patients with Diabetes guideline. For the prevention of macroangiopathy in younger patients, there seemed to be an advantage in maintaining HbA1c within the range of 6.0-6.9% and <7.0% based on the Evidence-based Practice Guideline for the Treatment for Diabetes in Japan 2013 and the Japan Diabetes Society and the Japan Geriatrics Society Joint Committee on Improving Care for Elderly Patients with Diabetes, respectively.

conclusionsIn all type 2 diabetes mellitus patients, average HbA1c should be maintained <7.0% to prevent microangiopathy. However, in elderly patients, no optimal target for preventing macroangiopathy was found, in contrast to the younger patients in the present study.

Indexed as

AgedBiomarkersBlood GlucoseCase-Control StudiesDiabetes Mellitus, Type 2Diabetic AngiopathiesFemaleFollow-Up StudiesGlycated HemoglobinHumansLongitudinal StudiesMaleMiddle AgedOutpatientsPrognosisRetrospective StudiesBiomarkersBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanJapanese type 2 diabetesJDS/JGS guidelineKumamoto Declaration

Identifiers

PMID30099853
PMCPMC6400169

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.