ArticleJournal of applied clinical medical physics2018
Energy-dependent OAR sparing and dose conformity for total marrow irradiation of obese patients.
Article in Journal of applied clinical medical physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Feasibility study of total marrow lymphoid irradiation with volumetric modulated arc therapy: clinical implementation in a tertiary care center.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2023Trial
- Review
- Considerations for intensity modulated total body or total marrow and lymphoid irradiation.Clinical and translational radiation oncology · 2023Article
- Total marrow lymphoid irradiation IMRT treatment using a novel CT-linac.European journal of medical research · 2023Article
- Total marrow and lymphoid irradiation with helical tomotherapy: a practical implementation report.Radiation oncology journal · 2020Article
- Organ sparing of linac-based targeted marrow irradiation over total body irradiation.Journal of applied clinical medical physics · 2019Article
- Total marrow irradiation for hematopoietic malignancies using volumetric modulated arc therapy: A review of treatment planning studies.Physics and imaging in radiation oncology · 2019Review
- Effect of changes in monitor unit rate and energy on dose rate of total marrow irradiation based on Linac volumetric arc therapy.Radiation oncology (London, England) · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the effect on target coverage and organs at risk sparing by using 10 versus 6 MV for VMAT total marrow irradiation of obese patients. METHODS AND MATERIALS: Twenty-six total marrow irradiation, TMI, treatment plans delivered between December 2014 and June 2017 were reviewed and 10 were chosen for replanning based on patient characteristics and plan metrics. Beam geometry and isocenter placement were conserved, energy was changed from 6 to 10 MV and plans were reoptimized. Resulting dose distributions were compared to original plans to evaluate any potential advantage of choosing one energy over the other.
resultsTarget coverage and total monitor units were consistent between the 6 and 10 MV plans when averaged over all ten patients. Improvement in the conformity index (-11.0%, P = 0.009) when using 10 MV was statistically significant compared to the 6 MV plans. Volumes of normal tissue receiving 50%, 75%, and 90% Rx all decreased for the 10 MV plans compared to the original 6 MV plans. The mean dose to individual OARs decreased significantly for all investigated structures except for the lenses, oral cavity, and genitalia. The largest decreases in D
conclusionsUse of a higher energy 10 MV beam provided similar dose to target while achieving increased OAR and normal tissue sparing for the patients reviewed in this study.
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