Evidence map›Paper›PMID 30099652›Full record

SynthesisDigestive diseases and sciences2019

Effects of Probiotics on Inflammation and Uremic Toxins Among Patients on Dialysis: A Systematic Review and Meta-Analysis.

Charat Thongprayoon, Wisit Kaewput, Spencer T Hatch, Tarun Bathini, Konika Sharma, Karn Wijarnpreecha, Patompong Ungprasert, Matthew D'Costa, Michael A Mao, Wisit Cheungpasitporn

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Digestive diseases and sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 7 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 7 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
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  3. Renal failure · 2022
    Pooled it
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  6. Biotic Supplements in Patients With Chronic Kidney Disease: Meta-Analysis of Randomized Controlled Trials.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2022
    Pooled it
  7. Pooled it
  8. Article
  9. Review
  10. Review
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  13. The AKI-to-CKD Transition: The Role of Uremic Toxins.International journal of molecular sciences · 2023
    Review
  14. Article
  15. Article
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  17. Review
  18. Article
  19. mSystems · 2021
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Charat ThongprayoonDepartment of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA.
Wisit KaewputDepartment of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand.
Spencer T HatchDivision of Nephrology, Department of Medicine, University of Mississippi Medical Center, 2500 N. State St., Jackson, MS, 39216, USA.
Tarun BathiniDepartment of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA.
Konika SharmaDepartment of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA.
Karn WijarnpreechaDepartment of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA.
Patompong UngprasertClinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Matthew D'CostaDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Michael A MaoDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Wisit CheungpasitpornDivision of Nephrology, Department of Medicine, University of Mississippi Medical Center, 2500 N. State St., Jackson, MS, 39216, USA. wcheungpasitporn@gmail.com.ORCID 0000-0001-9954-9711
Bassett Medical Center · USMayo Clinic · USUniversity of Mississippi Medical Center · USPhramongkutklao Hospital · THSiriraj Hospital · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesWe performed this systematic review and meta-analysis to evaluate effects of probiotics on inflammation, uremic toxins, and gastrointestinal (GI) symptoms in end-stage renal disease (ESRD) patients.

methodsA literature search was conducted utilizing MEDLINE, EMBASE, and Cochrane Database from inception through October 2017. We included studies that assessed assessing effects of probiotics on inflammatory markers, protein-bound uremic toxins (PBUTs), and GI symptoms in ESRD patients on dialysis. Effect estimates from the individual study were extracted and combined utilizing random effect, generic inverse variance method of DerSimonian and Laird. The protocol for this meta-analysis is registered with PROSPERO; No. CRD42017082137.

resultsSeven clinical trials with 178 ESRD patients were enrolled. There was a significant reduction in serum C-reactive protein (CRP) from baseline to post-probiotic course (≥ 2 months after treatment) with standardized mean difference (SMD) of - 0.42 (95% CI - 0.68 to - 0.16, p = 0.002). When compared to control, patients who received probiotics also had a significant higher degree of reduction in CRP level with SMDs of - 0.37 (95% CI - 0.72 to 0.03, p = 0.04). However, there were no significant changes in serum TNF-alpha or albumin with SMDs of - 0.32 (95% CI - 0.92 to 0.28, p = 0.29) and 0.16 (95% CI - 0.20 to 0.53, p = 0.39), respectively. After probiotic course, there were also significant decrease in PBUTs and improvement in overall GI symptoms (reduction in GI symptom scores) with SMDs of - 0.61 (95% CI - 1.16 to - 0.07, p = 0.03) and - 1.04 (95% CI - 1.70 to - 0.38, p = 0.002), respectively.

conclusionOur study demonstrates potential beneficial effects of probiotics on inflammation, uremic toxins, and GI Symptoms in ESRD patients. Future large-scale clinical studies are required to assess its benefits on other important clinical outcomes including patient mortality.

Indexed as

Renal DialysisC-Reactive ProteinGastrointestinal DiseasesHumansInflammationKidney Failure, ChronicProbioticsSerum AlbuminTumor Necrosis Factor-alphaUremiaC-Reactive ProteinSerum AlbuminTumor Necrosis Factor-alphaDialysisEnd-stage renal diseaseESRDGut microbiomeProbioticsUremic toxins

Identifiers

PMID30099652
OpenAlexW2886181189

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.