ArticleHistochemistry and cell biology2019
Characterization of the human ridged and non-ridged skin: a comprehensive histological, histochemical and immunohistochemical analysis.
Article in Histochemistry and cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- "Shedding the status"-a meta-analysis on the individual propensity to shed skin material in the context of forensic trace analysis.International journal of legal medicine · 2025Pooled it
- Analysis of Histostructural Modifications in the Ocular Surface of Patients With Chronic Glaucoma.Investigative ophthalmology & visual science · 2026Article
- Generation and ex vivo characterization of a full-thickness substitute of the human urethra by tissue engineering.Bioengineering & translational medicine · 2026Article
- A Cross-Sectional Study Exploring the Suitability of Skin Hydration Measurement Devices for Use on the Foot.Journal of foot and ankle research · 2025Article
- Generation of a Bioengineered Substitute of the Human Sclero-Corneal Limbus Using a Novel Decellularization Method.Pharmaceutics · 2025Article
- Rethinking treatment strategies for second-degree palmar burns in adults: A ten-year retrospective outcome analysis at a major burn center.JPRAS open · 2025Article
- A comprehensive analysis of two types of xenogeneic bone particles for use in maxillofacial bone regeneration therapies.PloS one · 2025Article
- Spatiotemporal characterization of extracellular matrix maturation in human artificial stromal-epithelial tissue substitutes.BMC biology · 2024Article
- Histological, histochemical, and immunohistochemical characterization of NANOULCOR nanostructured fibrin-agarose human cornea substitutes generated by tissue engineering.BMC medicine · 2024Article
- Structural and molecular characteristics of weight-bearing volar skin can be reconstituted by micro skin tissue column grafting.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Friction Blisters of the Feet: A New Paradigm to Explain Causation.Journal of athletic training · 2024Article
- Development of a Tissue Oxygenation Flow-Based Index Toward Discerning the Healing Status in Diabetic Foot Ulcers.Advances in wound care · 2024Article
- Histological assessment of nanostructured fibrin-agarose skin substitutes grafted in burnt patients. A time-course study.Bioengineering & translational medicine · 2023Article
- Fractional carbon dioxide laser alone and as an assisted drug delivery for treatment of alopecia areata: a clinical, dermoscopic and immunohistochemical study.Archives of dermatological research · 2023Article
- Molecular and Cellular Characterization of Avian Reticulate Scales Implies the Evo-Devo Novelty of Skin Appendages in Foot Sole.Journal of developmental biology · 2023Article
- Molecules involved in the sperm interaction in the human uterine tube: a histochemical and immunohistochemical approach.European journal of histochemistry : EJH · 2023Article
- Protective Barriers Provided by the Epidermis.International journal of molecular sciences · 2023Review
- Differential cell composition and split epidermal differentiation in human palm, sole, and hip skin.Cell reports · 2023Article
- The case for considering volar skin in a "separate status" for wound healing.Frontiers in medicine · 2023Review
- Development of stromal differentiation patterns in heterotypical models of artificial corneas generated by tissue engineering.Frontiers in bioengineering and biotechnology · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The structure of the human skin is directly dependent on its location and the mechanical forces to which it is subjected. In the present work, we have performed a comprehensive analysis of the human ridged and non-ridged skin to identify the differences and similarities between both skin types. For this purpose, human skin samples were obtained from dorsal hand skin (DHS), palmar hand skin (PHS), dorsal foot skin (DFS) and plantar foot skin (PFS) from the same cadaveric donors. Histological, histochemical and semiquantitative and quantitative immunohistochemical analyses were carried out to evaluate the epidermis, dermis and basement membrane. Results show that the epithelial layer of ridged skin had larger cell number and size than non-ridged skin for most strata. Melanocytes and Langerhans cells were more abundant in non-ridged skin, whereas Merkel cells were preferentially found in ridged skin. The expression pattern of CK5/6 was slightly differed between non-ridged and ridged skin. Involucrin expression was slightly more intense in non-ridged skin than in ridged skin. Collagen was more abundant in foot skin dermis than in hand skin, and in ridged skin as compared to non-ridged skin. Elastic fibers were more abundant in DHS. Biglycan was more abundant in foot skin than in hand skin. No differences were found for blood and lymphatic vessels. The basement membrane laminin was preferentially found in foot skin. These results revealed important differences at the epithelial, dermal and basement membrane levels that could contribute to a better knowledge of the human skin histology.
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