Evidence map›Paper›PMID 30099488›Full record

ArticleAmerican journal of epidemiology2018

Live-Birth Bias and Observed Associations Between Air Pollution and Autism.

Raanan Raz, Marianthi-Anna Kioumourtzoglou, Marc G Weisskopf

Open access · bronzeAbstract read
In one paragraph

Article in American journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Prenatal exposure to wildfire-related PMEnvironment international · 2026
    Article
  4. Article
  5. A novel approach for inferring effects on pregnancy loss.American journal of epidemiology · 2025
    Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Raanan RazBraun School of Public Health and Community Medicine, the Hebrew University of Jerusalem, Jerusalem, Israel.
Marianthi-Anna KioumourtzoglouDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York City, New York.
Marc G WeisskopfDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Columbia University · USHarvard University · USHebrew University of Jerusalem · IL

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
Air Pollution and Autism in Israel: A Population-Wide StudyR21ES026900 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI WEISSKOPF, MARC G · 2016 to 2017
$391k
NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30 ES009089NIEHS NIH HHS R21 ES026900
6 · The paper itself

Abstract

A recent analysis found that exposure to air pollution during specific weeks of pregnancy was negatively associated with risk of autism spectrum disorder (ASD) when mutually adjusted for postnatal air-pollution exposure. In this commentary, we describe 2 possible selection-bias processes that might lead to such results, both related to live-birth bias (i.e., the inevitable restriction of the analyzed sample to live births). The first mechanism is described using a directed acyclic graph and relates to the chance of live birth being a common consequence of both exposure to air pollution and another risk factor of ASD. The second mechanism involves preferential depletion of fetuses susceptible to ASD in the higher air-pollution exposure group. We further discuss the assumptions underlying these processes and their causal structures, their plausibility, and other studies where similar phenomena might have occurred.

Indexed as

Autism Spectrum DisorderBiasEpidemiologic MethodsFemaleHumansLive BirthMaternal ExposureNitrogen DioxideOzonePregnancyPregnancy OutcomePregnancy TrimestersPrenatal Exposure Delayed EffectsReproducibility of ResultsRisk FactorsSeasonsNitrogen DioxideOzone

Identifiers

PMID30099488
PMCPMC6211245
OpenAlexW2887982491

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.