ArticleNeuroscience2019
Primary Neural Degeneration in the Human Cochlea: Evidence for Hidden Hearing Loss in the Aging Ear.
Article in Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06729632 (Non-Invasive System to Deliver Therapeutic Hypothermia for Protection Against Noise-Induced Hearing Loss), which is not on this map. Cited by 254 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Non-Invasive System to Deliver Therapeutic Hypothermia for Protection Against Noise-Induced Hearing Loss
Who cites it
254 citing papers in PubMed, 2 syntheses or guidelines pooled it, 431 citations in OpenAlex.
- Effects of age and noise exposure history on auditory nerve response amplitudes: A systematic review, study, and meta-analysis.Hearing research · 2024Pooled it
- Detecting Noise-Induced Cochlear Synaptopathy by Auditory Brainstem Response in Tinnitus Patients With Normal Hearing Thresholds: A Meta-Analysis.Frontiers in neuroscience · 2021Pooled it
- Single Intratympanic Injection of Proprietary Brain-Derived Neurotrophic Factor (OTO-413) in Subjects with Speech-in-Noise Hearing Impairment: a Randomized, Dose Escalating, Double-Blind, Placebo-Controlled Phase 1/2 Study.Journal of the Association for Research in Otolaryngology : JARO · 2026Trial
- Electrically evoked compound action potentials in adult and pediatric cochlear implant users: I. Cochlear nerve responsiveness and electrode-neuron interface index.Hearing research · 2026Article
- Longitudinal Audiological and Vestibular Follow-up in Adult Cancer Patients Receiving Platinum-Based Chemotherapy.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Auditory brainstem response amplitude predicts age-related forward masking temporal-processing deficits in normal-hearing listeners.bioRxiv : the preprint server for biology · 2026Article
- Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS-Initiated Neuroinflammation and BK Channel Suppression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cochlear aging after synaptopathic noise: age-noise interactions in hair cell loss and axonal degeneration.Hearing research · 2026Article
- Aging Alters Hair Cell Physiological Properties in Mice With Late-Onset Age-Related Hearing Loss.Aging cell · 2026Article
- Speech Recognition Deficits in Presbyacusis: Links to Cortical Structural and Functional Alterations.World journal of otorhinolaryngology - head and neck surgery · 2026Article
- Short-term test-retest reliability of a few proxy measures of cochlear synaptopathy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Electrically evoked compound action potentials in adult and pediatric cochlear implant users: II. Assessing cochlear nerve health status with the interphase gap effect and the phase locking value.Hearing research · 2026Article
- Evaluating the N1-P2 Interpeak Latency of the eCAP and Its Intertrial Variability as Potential Indicators of Neural Synchrony in the Auditory Nerve of Cochlear Implant Users.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Acoustic Scene-Aware Processing and Auditory Model-Based Compensation Strategies.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- Molecularly defined auditory neuron subtypes show different vulnerabilities to noise- and age-related synaptopathy in mice.Nature communications · 2026Article
- Presbycusis Across the Lifespan: Genetic, Molecular, and Multi-Omics Contributions.Audiology research · 2026Review
- Parallel Age-Related Cochlear Neural Degeneration and Cortical Gain Adaptation in Normal-Hearing Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Pre-treatment audiological and vestibular assessment in adults starting platinum-based chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Hearing Aids: What Works Well and What Can Be Improved.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
194 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The noise-induced and age-related loss of synaptic connections between auditory-nerve fibers and cochlear hair cells is well-established from histopathology in several mammalian species; however, its prevalence in humans, as inferred from electrophysiological measures, remains controversial. Here we look for cochlear neuropathy in a temporal-bone study of "normal-aging" humans, using autopsy material from 20 subjects aged 0-89 yrs, with no history of otologic disease. Cochleas were immunostained to allow accurate quantification of surviving hair cells in the organ Corti and peripheral axons of auditory-nerve fibers. Mean loss of outer hair cells was 30-40% throughout the audiometric frequency range (0.25-8.0 kHz) in subjects over 60 yrs, with even greater losses at both apical (low-frequency) and basal (high-frequency) ends. In contrast, mean inner hair cell loss across audiometric frequencies was rarely >15%, at any age. Neural loss greatly exceeded inner hair cell loss, with 7/11 subjects over 60 yrs showing >60% loss of peripheral axons re the youngest subjects, and with the age-related slope of axonal loss outstripping the age-related loss of inner hair cells by almost 3:1. The results suggest that a large number of auditory neurons in the aging ear are disconnected from their hair cell targets. This primary neural degeneration would not affect the audiogram, but likely contributes to age-related hearing impairment, especially in noisy environments. Thus, therapies designed to regrow peripheral axons could provide clinically meaningful improvement in the aged ear.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.