ArticleOsteoarthritis and cartilage2018
Contribution of central and peripheral risk factors to prevalence, incidence and progression of knee pain: a community-based cohort study.
Article in Osteoarthritis and cartilage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predicting response to topical non-steroidal anti-inflammatory drugs in osteoarthritis: an individual patient data meta-analysis of randomized controlled trials.Rheumatology (Oxford, England) · 2020Pooled it
- Feasibility of conducting a cohort randomized controlled trial assessing the effectiveness of a nurse-led package of care for knee pain.Rheumatology (Oxford, England) · 2024Trial
- Associations between osteoarthritis and comorbidities before and after diagnosis across four European primary care databases: a multinational case-control and cohort study.The Lancet regional health. Europe · 2026Article
- Occupational physical behaviors and knee pain among eldercare workers: A prospective accelerometer study.Scandinavian journal of work, environment & health · 2026Article
- Genetic markers for knee osteoarthritis presence are not associated with disease progression - data from the IMI-APPROACH cohort.PloS one · 2025Article
- A Study on Imaging Risk Factors for Hip Osteoarthritis.Orthopaedic surgery · 2024Article
- The challenge of pharmacotherapy for musculoskeletal pain: an overview of unmet needs.Therapeutic advances in musculoskeletal disease · 2024Review
- Article
- Associations of Muscle Strength with Central Aspects of Pain: Data from the Knee Pain and Related Health in the Community (KPIC) Cohort.Journal of personalized medicine · 2023Article
- Article
- Comorbidities and use of analgesics in people with knee pain: a study in the Nottingham Knee Pain and Health in the Community (KPIC) cohort.Rheumatology advances in practice · 2022Article
- Association of depressive symptoms and risk of knee pain: the moderating effect of sex.BMC musculoskeletal disorders · 2021Article
- Prevalence of ultrasound-detected knee synovial abnormalities in a middle-aged and older general population-the Xiangya Osteoarthritis Study.Arthritis research & therapy · 2021Article
- [Prevention of chronic pain in the German healthcare system : Current state and perspective].Schmerz (Berlin, Germany) · 2021Review
- Investigating musculoskeletal health and wellbeing; a cohort study protocol.BMC musculoskeletal disorders · 2020Article
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7 authors.
Funding
Abstract
aimTo explore risk factors that may influence knee pain (KP) through central or peripheral mechanisms.
methodsA questionnaire-based prospective community cohort study with KP defined as pain in or around a knee on most days for at least a month. Baseline prevalence, and one year incidence and progression (KP worsening) were examined. Central (e.g., Pain Catastrophizing Scale (PCS)) and peripheral (e.g., significant injury) risk factors were examined. Adjusted odds ratio (OR) and 95% confidence interval (CI) were calculated using logistic regression. Proportional risk contribution (PRC) was estimated using receiver-operator-characteristic (ROC) analysis.
resultsOf 9506 baseline participants, 4288 (45%) had KP (men 1826; women, 2462). KP incidence was 12% (men 11%, women 13%), and KP progression 19% (men 16%, women 21%) at one year. While both central and peripheral factors contributed to prevalence, central factors contributed more to progression, and peripheral factors more to incidence of KP. For example, although PCS (OR 2.06, 95% CI 1.88-2.25) and injury (5.62, 4.92-6.42) associated with KP prevalence, PCS associated with progression (2.27, 1.83-2.83) but not incidence (1.14, 0.86-1.52), whereas injury more strongly associated with incidence (69.27, 24.15-198.7) than progression (2.52, 1.48-4.30). The PRC of central and peripheral factors were 19% and 23% for prevalence, 14% and 29% for incidence, and 29% and 5% for progression, respectively.
conclusionsBoth central and peripheral risk factors influence KP but relative contributions may differ in terms of development (mainly peripheral) and progression (mainly central). Further study of such relative contributions may inform primary and secondary prevention strategies.
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