Evidence map›Paper›PMID 30099076›Full record

ArticleNeuroImage2018

Comparing fully automated state-of-the-art cerebellum parcellation from magnetic resonance images.

Aaron Carass, Jennifer L Cuzzocreo, Shuo Han, Carlos R Hernandez-Castillo, Paul E Rasser, Melanie Ganz, Vincent Beliveau, Jose Dolz, Ismail Ben Ayed, Christian Desrosiers and 13 more

Abstract readComparative Study
In one paragraph

Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

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  10. Mapping Cerebellar Morphology in 15q11.2 CNV Carriers Using Normative Modeling.medRxiv : the preprint server for health sciences · 2025
    Article
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Aaron CarassDepartment of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD, 21218, USA; Department of Computer Science, The Johns Hopkins University, Baltimore, MD, 21218, USA. Electronic address: aaron_carass@jhu.edu.
Jennifer L CuzzocreoDepartment of Radiology, The Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA.
Shuo HanDepartment of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, 21218, USA; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, 20892, USA.
Carlos R Hernandez-CastilloConsejo Nacional de Ciencia y Tecnología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Mexico.
Paul E RasserPriority Research Centre for Brain & Mental Health and Stroke & Brain Injury, University of Newcastle, Callaghan, NSW, Australia.
Melanie GanzNeurobiology Research Unit, Rigshospitalet, Copenhagen, Denmark; Department of Computer Science, University of Copenhagen, Copenhagen, Denmark.
Vincent BeliveauNeurobiology Research Unit, Rigshospitalet, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jose DolzLaboratory for Imagery, Vision, and Artificial Intelligence, École de Technologie Supérieure, Montreal, QC, Canada.
Ismail Ben AyedLaboratory for Imagery, Vision, and Artificial Intelligence, École de Technologie Supérieure, Montreal, QC, Canada.
Christian DesrosiersLaboratory for Imagery, Vision, and Artificial Intelligence, École de Technologie Supérieure, Montreal, QC, Canada.
Benjamin ThyreauInstitute of Development, Aging and Cancer, Tohoku University, Japan.
José E RomeroInstituto Universitario de Tecnologías de la Información y Comunicaciones (ITACA), Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain.
Pierrick CoupéUniversity of Bordeaux, LaBRI, UMR 5800, PICTURA, Talence, F-33400, France; CNRS, LaBRI, UMR 5800, PICTURA, Talence, F-33400, France.
José V ManjónInstituto Universitario de Tecnologías de la Información y Comunicaciones (ITACA), Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain.
Vladimir S FonovImage Processing Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
D Louis CollinsImage Processing Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Sarah H YingDepartment of Neurology, The Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA.
Chiadi U OnyikeDepartment of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA.
Deana CrocettiCenter for Neurodevelopmental Medicine and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, 21205, USA.
Bennett A LandmanDepartment of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, 37235, USA.
Stewart H MostofskyCenter for Neurodevelopmental Medicine and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, 21205, USA; Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA; Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, CA, 90292, USA; Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology, University of Southern California, Los Angeles, CA, 90033, USA.
Jerry L PrinceDepartment of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD, 21218, USA; Department of Computer Science, The Johns Hopkins University, Baltimore, MD, 21218, USA.

Funding

Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Neurology of Deficient Response Control in ADHDR01MH085328 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI MOSTOFSKY, STEWART H · 2009 to 2019
$7.3M
Anomalous Motor Physiology In ADHDR01MH078160 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI MOSTOFSKY, STEWART H · 2006 to 2024
$5.8M
Automatic Cerebellar MRI Labeling In Health and DiseaseR01NS056307 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PRINCE, JERRY L · 2006 to 2015
$3.0M
Robust Cerebrum and Cerebellum Segmentation for Neuroimage AnalysisR21EB009900 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI PRINCE, JERRY L · 2009 to 2010
$457k
NIBIB NIH HHS R21 EB009900NIBIB NIH HHS U54 EB020403NIMH NIH HHS R01 MH078160NIMH NIH HHS R01 MH085328NINDS NIH HHS R01 NS056307
6 · The paper itself

Abstract

The human cerebellum plays an essential role in motor control, is involved in cognitive function (i.e., attention, working memory, and language), and helps to regulate emotional responses. Quantitative in-vivo assessment of the cerebellum is important in the study of several neurological diseases including cerebellar ataxia, autism, and schizophrenia. Different structural subdivisions of the cerebellum have been shown to correlate with differing pathologies. To further understand these pathologies, it is helpful to automatically parcellate the cerebellum at the highest fidelity possible. In this paper, we coordinated with colleagues around the world to evaluate automated cerebellum parcellation algorithms on two clinical cohorts showing that the cerebellum can be parcellated to a high accuracy by newer methods. We characterize these various methods at four hierarchical levels: coarse (i.e., whole cerebellum and gross structures), lobe, subdivisions of the vermis, and the lobules. Due to the number of labels, the hierarchy of labels, the number of algorithms, and the two cohorts, we have restricted our analyses to the Dice measure of overlap. Under these conditions, machine learning based methods provide a collection of strategies that are efficient and deliver parcellations of a high standard across both cohorts, surpassing previous work in the area. In conjunction with the rank-sum computation, we identified an overall winning method.

Indexed as

Machine LearningAdultAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderCerebellar AtaxiaCerebellumChildCohort StudiesFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeuroimagingAttention deficit hyperactivity disorderAutismCerebellar ataxiaMagnetic resonance imaging

Identifiers

PMID30099076
PMCPMC6271471

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.