Evidence map›Paper›PMID 30098651›Full record

ReviewThe Psychiatric clinics of North America2018

Deep Brain Stimulation in Psychiatry: Mechanisms, Models, and Next-Generation Therapies.

Mustafa Taha Bilge, Aishwarya K Gosai, Alik S Widge

Abstract readReview
In one paragraph

Review in The Psychiatric clinics of North America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Recent developments in treatments for eating disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
  4. Review
  5. Neurostimulation to Improve Cognitive Flexibility.Current opinion in behavioral sciences · 2025
    Article
  6. Review
  7. Review
  8. Paradigm shift in psychiatric treatments: Brain stimulation.Dusunen adam : Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi yayin organi · 2024
    Article
  9. Article
  10. The future of brain circuit-targeted therapeutics.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mustafa Taha BilgeDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Boston, MA 02129, USA.
Aishwarya K GosaiDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Boston, MA 02129, USA.
Alik S WidgeDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Boston, MA 02129, USA; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: awidge@partners.org.

Funding

Combined Cortical and Subcortical Recording and Stimulation as a Circuit-Oriented Treatment for Obsessive-Compulsive DisorderUH3NS100548 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI DOUGHERTY, DARIN D, WIDGE, ALIK S. · 2016 to 2024
$3.2M
Synchronizing a Fear Regulation Circuit By Temporally Patterned Closed-LoopNeurostimulationR21MH109722 · NIMH · UNIVERSITY OF MINNESOTA · PI WIDGE, ALIK S. · 2016 to 2017
$444k
Computational Modeling of Deep Brain Stimulation of the Ventral StriatumR03MH111320 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DOUGHERTY, DARIN D, WIDGE, ALIK S. · 2016 to 2016
$183k
NIMH NIH HHS R03 MH111320NIMH NIH HHS R21 MH109722NINDS NIH HHS UH3 NS100548
6 · The paper itself

Abstract

Deep brain stimulation has preliminary evidence of clinical efficacy, but has been difficult to develop into a robust therapy, in part because its mechanisms are incompletely understood. We review evidence from movement and psychiatric disorder studies, with an emphasis on how deep brain stimulation changes brain networks. From this, we argue for a network-oriented approach to future deep brain stimulation studies. That network approach requires methods for identifying patients with specific circuit/network deficits. We describe how dimensional approaches to diagnoses may aid that identification. We discuss the use of network/circuit biomarkers to develop self-adjusting "closed loop" systems.

Indexed as

Deep Brain StimulationElectrophysiological PhenomenaHumansMental DisordersNerve NetPsychiatryClosed-loop DBSDBS in psychiatryDimension-oriented psychiatryMechanisms of DBSNetwork-oriented DBS

Identifiers

PMID30098651
PMCPMC6092041

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.