Evidence map›Paper›PMID 30098602›Full record

Observational studyBMC pediatrics2018

Does red blood cell irradiation and/or anemia trigger intestinal injury in premature infants with birth weight ≤ 1250 g? An observational birth cohort study.

Terri Marin, Ravi M Patel, John D Roback, Sean R Stowell, Ying Guo, Kirk Easley, Megan Warnock, Jane Skvarich, Cassandra D Josephson

Registry-linked trialOpen access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02741648 (Red Blood Cell Transfusion and Digestive Tract Oxygenation in Preterm Infants Weighing ≤ 1250 Grams), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02741648 completednot on this map

Red Blood Cell Transfusion and Digestive Tract Oxygenation in Preterm Infants Weighing ≤ 1250 Grams

TypeobservationalSponsorEmory UniversityRan2016 to 2026Enrolled324ConditionsAnemia, Necrotizing EnterocolitisArmsNear Infrared Spectroscopy, Non-invasive Image-based Anemia Assessment
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Observational
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Terri MarinDepartment of Physiological and Technological Nursing, Augusta University, College of Nursing, 1120 15th Street, EC-5354, Augusta, GA, 30912, USA. tmarin@augusta.edu.ORCID 0000-0001-9541-0472
Ravi M PatelDepartment of Pediatrics, Emory University, School of Medicine, 2015 Uppergate Drive, Atlanta, GA, 30322, USA.
John D RobackDepartment of Pathology and Laboratory Medicine, Emory University, School of Medicine, 1364 Clifton Rd NE, Atlanta, GA, 30322, USA.
Sean R StowellDepartment of Pathology and Laboratory Medicine, Emory University, School of Medicine, 1364 Clifton Rd NE, Atlanta, GA, 30322, USA.
Ying GuoDepartment of Biostatistics and Bioinformatics, Emory University, School of Public Health, 1518 Clifton Rd, Atlanta, GA, 30322, USA.
Kirk EasleyDepartment of Biostatistics and Bioinformatics, Emory University, School of Public Health, 1518 Clifton Rd, Atlanta, GA, 30322, USA.
Megan WarnockDepartment of Biostatistics and Bioinformatics, Emory University, School of Public Health, 1518 Clifton Rd, Atlanta, GA, 30322, USA.
Jane SkvarichDepartment of Pediatrics, Emory University, School of Medicine, 2015 Uppergate Drive, Atlanta, GA, 30322, USA.
Cassandra D JosephsonDepartment of Pediatrics, Emory University, School of Medicine, 2015 Uppergate Drive, Atlanta, GA, 30322, USA.
Emory University · USAugusta University · US

Funding

Serious Hazards of Transfusion & Cellular Therapies: Mechanisms and InterventionP01HL086773 · NHLBI · EMORY UNIVERSITY · PI ROBACK, JOHN D · 2008 to 2019
$17.9M
Red Cell Transfusion, Severe Anemia and Necrotizing EnterocolitisK23HL128942 · NHLBI · EMORY UNIVERSITY · PI PATEL, RAVI MANGAL · 2016 to 2019
$665k
NHLBI NIH HHS 2PO1 HL086773NHLBI NIH HHS K23 HL128942NHLBI NIH HHS P01 HL086773
6 · The paper itself

Abstract

backgroundNecrotizing enterocolitis (NEC) is a leading cause of neonatal morbidity and mortality in premature infants. To date, no effective biomarkers exist to predict which premature infants will develop NEC, limiting targeted prevention strategies. Multiple observational studies have reported an association between the exposure to red blood cell (RBC) transfusion and/or anemia and the subsequent development of NEC; however, the underlying physiologic mechanisms of how these factors are independently associated with NEC remain unknown.

methodsIn this paper, we outline our prospective, multicenter observational cohort study of infants with a birth weight ≤ 1250 g to investigate the associations between RBC transfusion, anemia, intestinal oxygenation and injury that lead to NEC. Our overarching hypothesis is that irradiation of RBC units followed by longer storage perturbs donor RBC metabolism and function, and these derangements are associated with paradoxical microvascular vasoconstriction and intestinal tissue hypoxia increasing the risk for injury and/or NEC in transfused premature infants with already impaired intestinal oxygenation due to significant anemia. To evaluate these associations, we are examining the relationship between prolonged irradiation storage time (pIST), RBC metabolomic profiles, and anemia on intestinal oxygenation non-invasively measured by near-infrared spectroscopy (NIRS), and the development of NEC in transfused premature infants. DISCUSSION: Our study will address a critical scientific gap as to whether transfused RBC characteristics, such as irradiation and metabolism, impair intestinal function and/or microvascular circulation. Given the multifactorial etiology of NEC, preventative efforts will be more successful if clinicians understand the underlying pathophysiologic mechanisms and modifiable risk factors influencing the disease.

trial registrationOur study is registered in ClinicalTrials.gov Identifier: NCT02741648 .

Indexed as

Infant, Very Low Birth WeightAnemia, NeonatalBlood PreservationCohort StudiesEnterocolitis, NecrotizingErythrocytesErythrocyte TransfusionHumansInfant, NewbornInfant, Premature, DiseasesOxygenResearch DesignSplanchnic CirculationOxygen

Identifiers

PMID30098602
PMCPMC6087009
OpenAlexW2885037637

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.