Evidence map›Paper›PMID 30098126›Full record

Trial reportDiabetes, obesity & metabolism2019

The effects of dietary supplementation with inulin and inulin-propionate ester on hepatic steatosis in adults with non-alcoholic fatty liver disease.

Edward S Chambers, Claire S Byrne, Annette Rugyendo, Douglas J Morrison, Tom Preston, Catriona Tedford, Jimmy D Bell, Louise Thomas, Arne N Akbar, Natalie E Riddell and 4 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes, obesity & metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 3 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 101 citations in OpenAlex.

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  6. Short-chain fatty acids.Nature metabolism · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 1 country.

Edward S ChambersSection for Nutrition Research, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK.ORCID 0000-0001-7074-1312
Claire S ByrneSection for Nutrition Research, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK.
Annette RugyendoSection for Nutrition Research, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK.
Douglas J MorrisonStable Isotope Biochemistry Laboratory, Scottish Universities Environmental Research Centre, University of Glasgow, Glasgow, UK.
Tom PrestonStable Isotope Biochemistry Laboratory, Scottish Universities Environmental Research Centre, University of Glasgow, Glasgow, UK.
Catriona TedfordSchool of Science, University of the West of Scotland, Hamilton, UK.
Jimmy D BellDepartment of Life Sciences, Faculty of Science and Technology, Research Centre for Optimal Health, University of Westminster, London, UK.
Louise ThomasDepartment of Life Sciences, Faculty of Science and Technology, Research Centre for Optimal Health, University of Westminster, London, UK.
Arne N AkbarDivision of Infection and Immunity, University College London, London, UK.
Natalie E RiddellFaculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Rohini SharmaDepartment of Surgery and Cancer, Imperial College London, London, UK.
Mark R ThurszDepartment of Surgery and Cancer, Imperial College London, London, UK.
Pinelopi ManousouLiver Unit, St Mary's Hospital, Imperial College NHS Trust, London, UK.
Gary FrostSection for Nutrition Research, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK.
Hammersmith Hospital · GBImperial College London · GBScottish Universities Environmental Research Centre · GBUniversity of Westminster · GBSt Mary's Hospital · GBUniversity College London · GBUniversity of Surrey · GBUniversity of the West of Scotland · GB

Funding

Biotechnology and Biological Sciences Research Council BB/G008272/1Department of Health EME/15/185/16Medical Research Council
6 · The paper itself

Abstract

The short chain fatty acid (SCFA) propionate, produced through fermentation of dietary fibre by the gut microbiota, has been shown to alter hepatic metabolic processes that reduce lipid storage. We aimed to investigate the impact of raising colonic propionate production on hepatic steatosis in adults with non-alcoholic fatty liver disease (NAFLD). Eighteen adults were randomized to receive 20 g/d of an inulin-propionate ester (IPE), designed to deliver propionate to the colon, or an inulin control for 42 days in a parallel design. The change in intrahepatocellular lipid (IHCL) following the supplementation period was not different between the groups (P = 0.082), however, IHCL significantly increased within the inulin-control group (20.9% ± 2.9% to 26.8% ± 3.9%; P = 0.012; n = 9), which was not observed within the IPE group (22.6% ± 6.9% to 23.5% ± 6.8%; P = 0.635; n = 9). The predominant SCFA from colonic fermentation of inulin is acetate, which, in a background of NAFLD and a hepatic metabolic profile that promotes fat accretion, may provide surplus lipogenic substrate to the liver. The increased colonic delivery of propionate from IPE appears to attenuate this acetate-mediated increase in IHCL.

Indexed as

Dietary SupplementsAdolescentAdultAgedEstersFatty Acids, VolatileFemaleGastrointestinal MicrobiomeHumansInulinLipid MetabolismLiverMaleMiddle AgedNon-alcoholic Fatty Liver DiseasePropionatesEstersFatty Acids, VolatileInulininulin-propionate esterPropionatesclinical trialdietary interventionfatty liverinsulin resistance

Identifiers

PMID30098126
PMCPMC6667894
OpenAlexW2885345054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.