ArticleEuropean journal of pain (London, England)2019
Behavioural and neural responses to aversive visceral stimuli in women with primary dysmenorrhoea.
Article in European journal of pain (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Neural correlates of acute task-related stress in humans: a systematic review and coordinate-based ALE meta-analysis.Brain imaging and behavior · 2026Pooled it
- Physical agents' level in women with primary dysmenorrhea: A cross-sectional observational study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Observational
- Bladder Pain Sensitivity Is a Potential Risk Factor for Irritable Bowel Syndrome.Digestive diseases and sciences · 2023Article
- Adaptive neuroplasticity in the default mode network contributing to absence of central sensitization in primary dysmenorrhea.Frontiers in neuroscience · 2023Article
- Cortical Mechanisms of Visual Hypersensitivity in Women at Risk for Chronic Pelvic Pain.medRxiv : the preprint server for health sciences · 2021Article
- Article
- Behavioural and neural responses to aversive visceral stimuli in women with primary dysmenorrhoea.European journal of pain (London, England) · 2019Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic pelvic pain, in particular dysmenorrhoea, is a significant yet unresolved healthcare problem in gynaecology. As interoceptive sensitivity and underlying neural mechanisms remain incompletely understood, this functional magnetic resonance imaging (fMRI) study assessed behavioural and neural responses to visceral stimuli in primary dysmenorrhoea (PMD).
methodsWomen with PMD (N = 19) without psychological comorbidity and healthy women (N = 20) were compared with respect to visceral sensory and pain thresholds, and to neural responses to individually calibrated mildly painful and painful rectal distensions implemented during scanning. Trial-by-trial ratings of perceived intensity were accomplished with visual analogue scales (VAS).
resultsAlthough women with dysmenorrhoea reported significantly higher chronic pain intensity and pain interference with daily life activities (p < 0.01, assessed with the West Haven-Yale Multidimensional Pain Inventory), there were no differences between groups in visceral sensitivity and mean trial-by-trial VAS ratings were virtually identical. Analysis of neural responses revealed activation in brain regions previously shown to be involved in the processing of visceral stimuli with differences between painful and mildly painful stimulation, but no group differences were found even when using a liberal statistical threshold.
conclusionsDysmenorrhoea patients show unaltered perceptual and neural responses to experimental interoceptive stimuli. Despite limited sample size, these negative results argue against a generalized sensitization towards interoceptive stimuli in patients without psychological comorbidities. Future studies should clarify the role of psychosocial factors in central sensitization using more pain region-specific models in larger and clinically more heterogeneous samples. SIGNIFICANCE: Despite higher chronic pain and pain interference with daily life activities, women with primary dysmenorrhoea do not differ from healthy women with respect to visceral sensitivity or neural processing of aversive interoceptive stimuli induced by rectal distensions. Generalized sensitization may be present only in subgroups with pronounced psychosocial or psychiatric disturbances.
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