Evidence map›Paper›PMID 30097920›Full record

ArticleBulletin of mathematical biology2018

Pattern Formation in the Longevity-Related Expression of Heat Shock Protein-16.2 in Caenorhabditis elegans.

J M Wentz, A R Mendenhall, D M Bortz

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Article in Bulletin of mathematical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. A free boundary mechanobiological model of epithelial tissues.Proceedings. Mathematical, physical, and engineering sciences · 2020
    Article
  4. Transcriptome-Based Analysis Reveals a Crucial Role ofInternational journal of molecular sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

J M WentzInterdisciplinary Quantitative Biology Graduate Program and Department of Applied Mathematics, University of Colorado, Boulder, CO, 80309-0526, USA.ORCID 0000-0002-7162-2283
A R MendenhallDepartment of Pathology, University of Washington, Seattle, WA, 98109-1024, USA.ORCID 0000-0002-4716-7671
D M BortzDepartment of Applied Mathematics, University of Colorado, Boulder, CO, 80309-0526, USA. dmbortz@colorado.edu.ORCID 0000-0003-1163-7317

Funding

Causes and consequences of lifespan biomarker variation in Caenorhabditis elegansR00AG045341 · NIA · UNIVERSITY OF WASHINGTON · PI MENDENHALL, ALEXANDER RICHARD · 2016 to 2018
$747k
NIA NIH HHS R00 AG045341
6 · The paper itself

Abstract

Aging in Caenorhabditis elegans is controlled, in part, by the insulin-like signaling and heat shock response pathways. Following thermal stress, expression levels of small heat shock protein-16.2 show a spatial patterning across the 20 intestinal cells that reside along the length of the worm. Here, we present a hypothesized mechanism that could lead to this patterned response and develop a mathematical model of this system to test our hypothesis. We propose that the patterned expression of heat shock protein is caused by a diffusion-driven instability within the pseudocoelom, or fluid-filled cavity, that borders the intestinal cells in C. elegans. This instability is due to the interactions between two classes of insulin-like peptides that serve antagonistic roles. We examine output from the developed model and compare it to experimental data on heat shock protein expression. Given biologically bounded parameters, the model presented is capable of producing patterns similar to what is observed experimentally and provides a first step in mathematically modeling aging-related mechanisms in C. elegans.

Indexed as

Models, BiologicalAgingAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsComputer SimulationGene Expression RegulationHeat-Shock ProteinsHeat-Shock ResponseHydrophobic and Hydrophilic InteractionsIntercellular Signaling Peptides and ProteinsIntestinal MucosaLongevityMathematical ConceptsPeptide HormonesCaenorhabditis elegans ProteinsDAF-2 protein, C elegansHeat-Shock Proteinshsp-16.2 protein, C elegansINS-18 protein, C elegansIntercellular Signaling Peptides and ProteinsPeptide HormonesReceptor, InsulinAgingDiffusion-driven instabilityInsulin-like signalingReaction diffusion model

Identifiers

PMID30097920
PMCPMC6162062

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.