Evidence map›Paper›PMID 30097827›Full record

ArticlePituitary2018

Optical coherence tomography retinal ganglion cell complex analysis for the detection of early chiasmal compression.

Richard J Blanch, Jonathan A Micieli, Nelson M Oyesiku, Nancy J Newman, Valérie Biousse

Abstract read
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In one paragraph

Article in Pituitary, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Richard J BlanchDepartment of Ophthalmology, Emory University School of Medicine, Atlanta, GA, USA.
Jonathan A MicieliDepartment of Ophthalmology, Emory University School of Medicine, Atlanta, GA, USA.
Nelson M OyesikuDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA.
Nancy J NewmanDepartment of Ophthalmology, Emory University School of Medicine, Atlanta, GA, USA.
Valérie BiousseDepartment of Ophthalmology, Emory University School of Medicine, Atlanta, GA, USA. vbiouss@emory.edu.
Emory University · USUniversity of Birmingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report patients with sellar tumors and chiasmal compression with normal visual fields, who demonstrate damage to the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) on optical coherence tomography (OCT).

methodsSeven patients with sellar tumors causing mass effect on the optic chiasm without definite visual field defect, but abnormal GCC are described. GCC/RNFL analyses using Cirrus-OCT were classified into centiles based on the manufacturer's reference range.

resultsIn seven patients with radiologic compression of the chiasm by a sellar tumor, OCT-GCC thickness detected compressive chiasmopathy before visual defects became apparent on standard automated visual field testing. Without OCT, our patients would have been labelled as having normal visual function and no evidence of compressive chiasmopathy. With only OCT-RNFL analysis, 3/7 patients would still have been labelled as having no compression of the anterior visual pathways.

conclusionsThese patients show that OCT-GCC analysis is more sensitive than visual field testing with standard automated perimetry in the detection of compressive chiasmopathy or optic neuropathy. These cases and previous studies suggest that OCT-GCC analysis may be used in addition to visual field testing to evaluate patients with lesions compressing the chiasm.

Indexed as

AdolescentAdultAgedChildFemaleHumansMaleMiddle AgedOptic Nerve DiseasesPituitary NeoplasmsRetinal Ganglion CellsRetrospective StudiesTomography, Optical CoherenceVisual FieldsYoung AdultChiasmal compressionGanglion cell complex analysisOptical coherence tomographyOptic neuropathyPituitary adenomaSellar massVisual field test

Identifiers

PMID30097827
OpenAlexW2885719140

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.