Evidence map›Paper›PMID 30097761›Full record

SynthesisNeuropsychology review2018

Social Function and Autism Spectrum Disorder in Children and Adults with Neurofibromatosis Type 1: a Systematic Review and Meta-Analysis.

Anita K Chisholm, Vicki A Anderson, Natalie A Pride, Stephanie Malarbi, Kathryn N North, Jonathan M Payne

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neuropsychology review, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 5 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 5 syntheses or guidelines pooled it, 72 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Anita K ChisholmMurdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia. anita.chisholm@mcri.edu.au.
Vicki A AndersonMurdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia.
Natalie A PrideInstitute for Neuroscience and Muscle Research, The Children's Hospital at Westmead, Sydney, Australia.
Stephanie MalarbiMurdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia.
Kathryn N NorthMurdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia.
Jonathan M PayneMurdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia. jonathan.payne@mcri.edu.au.
Murdoch Children's Research Institute · AURoyal Children's Hospital · AUChildren's Hospital at Westmead · AUUniversity of Melbourne · AU

Funding

National Health and Medical Research Council GNT1113949
6 · The paper itself

Abstract

In light of the proliferation of recent research into social function in neurofibromatosis type 1 (NF1), a systematic review and meta-analysis is required to synthesise data and place findings within the context of a theoretical framework. This paper reviews findings from research into social function and autism spectrum disorder (ASD) in children and adults with NF1 and integrates these findings with the Socio-Cognitive Integration Abilities Model (SOCIAL). It also critically appraises links between social outcomes, internal and external factors moderating social functioning, cognitive domains implicated in social functioning, and underlying neural pathology in NF1. A systematic literature search conducted in MedLine (Ovid), PsycINFO (Ovid), Embase (Ovid), and PubMed electronic databases yielded 35 papers that met inclusion criteria for the systematic review. Out of these papers, 22 papers provided sufficient data for meta-analysis. Findings from this review and meta-analysis provide evidence that children and adults with NF1 exhibit significantly higher prevalence and severity of social dysfunction and ASD symptomatology. To date, very few studies have examined social cognition in NF1 but results indicate the presence of both perceptual and higher-level impairments in this population. The results of this review also provide support for age, gender, and comorbid ADHD as moderating factors for social outcomes in NF1. Suggestions for future research are offered to further our understanding of the social phenotype in NF1 and to facilitate the development of targeted interventions.

Indexed as

Social BehaviorAdultAutism Spectrum DisorderChildHumansNeurofibromatosis 1Social PerceptionAutism spectrum disorderNeurofibromatosis type 1Social cognitionSocial functionSocial perception

Identifiers

PMID30097761
OpenAlexW2887111841

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.