Evidence map›Paper›PMID 30097684›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2019

Symptom patterns and clinical outcomes in women versus men with systolic heart failure and depression.

Sven M Piepenburg, Hermann Faller, Stefan Störk, Georg Ertl, Christiane E Angermann

Abstract read
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Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sven M PiepenburgDepartment of Medicine I, Comprehensive Heart Failure Center, University Hospital and University of Würzburg, Am Schwarzenberg 15, 97078, Würzburg, Germany.
Hermann FallerDepartment of Medical Psychology, Medical Sociology and Rehabilitation Sciences, University of Würzburg, Würzburg, Germany.
Stefan StörkDepartment of Medicine I, Comprehensive Heart Failure Center, University Hospital and University of Würzburg, Am Schwarzenberg 15, 97078, Würzburg, Germany.
Georg ErtlDepartment of Medicine I, Comprehensive Heart Failure Center, University Hospital and University of Würzburg, Am Schwarzenberg 15, 97078, Würzburg, Germany.
Christiane E AngermannDepartment of Medicine I, Comprehensive Heart Failure Center, University Hospital and University of Würzburg, Am Schwarzenberg 15, 97078, Würzburg, Germany. Angermann_c@ukw.de.
University of Würzburg · DEUniversitätsklinikum Würzburg · DEUniversity Medical Center Freiburg · DE

Funding

Bundesministerium für Bildung und Forschung 01GL0304Competence Network Heart Failure Germany 01GI0205Competence Network Heart Failure Germany 01GI1202AComprehensive Heart Failure Center Würzburg 01EO1004Comprehensive Heart Failure Center Würzburg 01EO1504
6 · The paper itself

Abstract

backgroundDepression is more common in females than in males and is 3-5 times more prevalent in patients with heart failure (HF) than in the general population. The 9-item Patient Health Questionnaire (PHQ-9) is a validated depression screening instrument; higher sum-scores predict adverse clinical outcomes. Sex- and gender differences in PHQ-9 symptom profile, diagnostic and prognostic properties, and impact on health-related quality of life (HRQOL) have not been comprehensively studied in HF patients. METHODS AND

resultsThis post hoc analysis from the Interdisciplinary Network Heart Failure program enrolled 852/1022 participants (67 ± 13 years, 28% female) who completed the PHQ-9 at hospital discharge after cardiac decompensation. All had a left ventricular ejection fraction ≤ 40%. Women had a higher mean PHQ-9 sum-score than men (8.4 ± 5.6 vs. 7.4 ± 5.5; p = 0.027), and higher proportions rated the following items ≥ 2 (i.e., present on ≥ 50% of days): 'feeling down, hopeless' (25.8 vs. 18.0%; p = 0.011); 'fatigue' (51.9 vs. 37.2%; p < 0.001); and 'trouble concentrating' (21.6 vs. 15.4%; p = 0.032). A PHQ-9 sum-score ≥ 10 predicted increased mortality in women [hazard ratio 1.91 (95% confidence interval 1.06-3.43); p = 0.030] and men [2.10 (1.43-3.09); p < 0.001] and was associated with worse HRQOL (p < 0.001 for all comparisons). Sum-scores ≥ 10 predicted higher re-hospitalization rates in men only [1.35 (1.08-1.69); p = 0.008].

conclusionsDifferences in several PHQ-9 items indicated sex- or gender-specific depression symptomatology in HF. For both sexes, HRQOL and survival were worse when PHQ-9 sum-score was ≥ 10, but higher sum-scores predicted higher re-hospitalization rates in men only. Considering these specific aspects might help optimize care strategies in HF.

Indexed as

Quality of LifeAgedDepressionEchocardiographyFemaleGermanyHeart Failure, SystolicHeart VentriclesHospitalizationHumansMaleMorbidityPrognosisRisk FactorsSex DistributionSex FactorsDepressionHeart failureMorbidityMortalitySex

Identifiers

PMID30097684
OpenAlexW2885146301

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.