Evidence map›Paper›PMID 30097683›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2019

Predictors of mortality in ischaemic versus non-ischaemic functional mitral regurgitation after successful transcatheter mitral valve repair using MitraClip: results from two high-volume centres.

Mitsunobu Kitamura, Hidehiro Kaneko, Michael Schlüter, Dimitry Schewel, Tobias Schmidt, Hannes Alessandrini, Felix Kreidel, Michael Neuss, Christian Butter, Karl-Heinz Kuck and 1 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Early results of a real-world series with two transapical transcatheter mitral valve replacement devices.Clinical research in cardiology : official journal of the German Cardiac Society · 2021
    Article
  10. Mitral valve leaflet repair with the new PASCAL system: early real-world data from a German multicentre experience.Clinical research in cardiology : official journal of the German Cardiac Society · 2020
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Mitsunobu KitamuraDepartment of Cardiology, Asklepios Klinik St. Georg, Lohmühlenstr. 5, 20099, Hamburg, Germany.ORCID http://orcid.org/0000-0002-7573-7176
Hidehiro KanekoHeart Center Brandenburg in Bernau/Berlin & Medical School Brandenburg (MHB), Bernau, Germany.
Michael SchlüterAsklepios Proresearch, Hamburg, Germany.
Dimitry SchewelDepartment of Cardiology, Asklepios Klinik St. Georg, Lohmühlenstr. 5, 20099, Hamburg, Germany.
Tobias SchmidtDepartment of Cardiology, Asklepios Klinik St. Georg, Lohmühlenstr. 5, 20099, Hamburg, Germany.
Hannes AlessandriniDepartment of Cardiology, Asklepios Klinik St. Georg, Lohmühlenstr. 5, 20099, Hamburg, Germany.
Felix KreidelDepartment of Cardiology, Asklepios Klinik St. Georg, Lohmühlenstr. 5, 20099, Hamburg, Germany.
Michael NeussHeart Center Brandenburg in Bernau/Berlin & Medical School Brandenburg (MHB), Bernau, Germany.
Christian ButterHeart Center Brandenburg in Bernau/Berlin & Medical School Brandenburg (MHB), Bernau, Germany.
Karl-Heinz KuckDepartment of Cardiology, Asklepios Klinik St. Georg, Lohmühlenstr. 5, 20099, Hamburg, Germany.
Christian FrerkerDepartment of Cardiology, Asklepios Klinik St. Georg, Lohmühlenstr. 5, 20099, Hamburg, Germany. c.frerker@asklepios.com.
Asklepios Klinik St. Georg · DEImmanuel Klinikum Bernau · DEAsklepios · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTranscatheter edge-to-edge mitral valve repair using the MitraClip has been widely performed in surgical high-risk patients with reduced left ventricular systolic function and severe functional mitral regurgitation (FMR). Ischaemic heart disease is the leading aetiology of heart disease worldwide. We aimed to assess the clinical implications of ischaemic aetiology in patients with severe FMR who underwent MitraClip implantation. METHODS AND

resultsFrom two high-volume centres in Germany, we retrospectively compared the clinical outcomes and clinical predictors of all-cause mortality after MitraClip implantation in patients with ischaemic (I-FMR) and non-ischaemic FMR (NI-FMR). In the overall FMR cohort (n = 575), there were 336 (58%) patients with I-FMR and 239 (42%) with NI-FMR. There was no significant difference in survival between the two groups (log-rank p = 0.78). In a multivariable Cox regression analysis of all-cause mortality, different predictors were observed for either group. In I-FMR patients, decreasing tricuspid annular systolic excursion [adjusted hazard ratio (HR

conclusionsDespite the similar survival between ischaemic and non-ischaemic FMR, different predictors of all-cause mortality were demonstrated. Further clinical studies are mandated to focus on each FMR subgroup with stratification by ischaemic origin.

Indexed as

AgedCardiac CatheterizationCause of DeathCoronary AngiographyCoronary VesselsFemaleGermanyHeart Valve Prosthesis ImplantationHeart VentriclesHospitals, High-VolumeHumansIncidenceMaleMitral ValveMitral Valve InsufficiencyMyocardial IschemiaFunctional mitral regurgitationIschaemic functional mitral regurgitationMitraClipNon-ischaemic functional mitral regurgitationTranscatheter edge-to-edge mitral valve repair

Identifiers

PMID30097683
OpenAlexW2885943449

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.