ArticleEuropean journal of human genetics : EJHG2018
On the loss of human sex chromosomes in lymphocytes with age: a quantitative treatment.
Article in European journal of human genetics : EJHG, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 5 citations in OpenAlex.
- Contextualizing the biological relevance of standardized high-resolution respirometry to assess mitochondrial function in permeabilized human skeletal muscle.Acta physiologica (Oxford, England) · 2021Article
- Insights into the loss of the Y chromosome with age in control individuals and in patients with age-related macular degeneration using genotyping microarray data.Human genetics · 2020Article
- Genetic and epigenetic Muller's ratchet as a mechanism of frailty and morbidity during aging: a demographic genetic model.Human genetics · 2020Article
- Darwinian selection within an individual or somatic selection: facts and models.Journal of molecular cell biology · 2019Article
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1 author at 1 institution in 1 country.
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Abstract
Increasing levels of aneuploidy of the sex chromosomes in human lymphocytes with age have been noted for several decades. The percentage of chromosome Y loss can reach up to 1.5% or even more, whereas the levels of X0 cells in females can increase up to 5% with age. Here, I propose simple mathematical models of the dynamics of 'normal' sex chromosome loss with age. These exponential models provide more mechanistic insights than linear regressions. They account for the lower incidence of sex chromosome loss in young individuals and its increase with age. Moreover, the exponential models show that aneuploidy of the sex chromosomes provides a selective advantage. As there are no longitudinal data available (for the same individual at different time points), the parameters reported here are average values derived from a population. Hopefully, this study will stimulate further work based on next-generation technologies to obtain better estimates of sex chromosome aneuploidy and of the parameters of the models discussed here.
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