Evidence map›Paper›PMID 30097597›Full record

ArticleScientific reports2018

Resting-state alpha power is selectively associated with autistic traits reflecting behavioral rigidity.

Virginia Carter Leno, Samuel B Tomlinson, Shou-An A Chang, Adam J Naples, James C McPartland

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Hypoxia alters the century old Berger effect.Frontiers in neuroscience · 2026
    Article
  3. Article
  4. Article
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Virginia Carter LenoYale Child Study Center, 230 South Frontage Road, New Haven, 06520, CT, USA.ORCID 0000-0002-7455-5514
Samuel B TomlinsonYale Child Study Center, 230 South Frontage Road, New Haven, 06520, CT, USA.
Shou-An A ChangYale Child Study Center, 230 South Frontage Road, New Haven, 06520, CT, USA.
Adam J NaplesYale Child Study Center, 230 South Frontage Road, New Haven, 06520, CT, USA.
James C McPartlandYale Child Study Center, 230 South Frontage Road, New Haven, 06520, CT, USA. james.mcpartland@yale.edu.

Funding

YALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8M
Neural markers of shared gaze during simulated social interactions in ASDR01MH100173 · NIMH · YALE UNIVERSITY · PI MCPARTLAND, JAMES CHARLES · 2013 to 2015
$1.3M
Developmental Social Neuroscience in Infants At-Risk for AutismK23MH086785 · NIMH · YALE UNIVERSITY · PI MCPARTLAND, JAMES CHARLES · 2010 to 2013
$725k
Multimodel Assessment of Social Process Systems across Neurodevelopmental DisordersR01MH107426 · NIMH · YALE UNIVERSITY · PI MCPARTLAND, JAMES CHARLES, SRIHARI, VINOD H. · 2015 to 2017
$651k
NCRR NIH HHS UL1 RR024139NIMH NIH HHS K23 MH086785NIMH NIH HHS R01 MH100173NIMH NIH HHS R01 MH107426
6 · The paper itself

Abstract

Previous research suggests that variation in at-rest neural activity correlates with specific domains of the ASD phenotype; however, few studies have linked patterns of brain activity with autistic trait expression in typically developing populations. The purpose of this study was to examine associations between resting-state electroencephalography (EEG) and three domains of the broader autism phenotype (social interest, rigidity, and pragmatic language) in typically developing individuals. High-density scalp EEG was recorded in thirty-seven typically developing adult participants (13 male, aged 18-52 years). The Broad Autism Phenotype Questionnaire (BAP-Q) was used to measure autistic trait expression. Absolute alpha power (8-13 Hz) was extracted from eyes-closed epochs using spectral decomposition techniques. Analyses revealed a specific positive association between scores on the BAP-Q Rigidity subscale and alpha power in the parietal scalp region. No significant associations were found between alpha power and the BAP-Q Aloofness or Pragmatic Language subscales. Furthermore, the association between EEG power and behavioral rigidity was specific to the alpha frequency band. This study demonstrates that specific traits within the broader autism phenotype are associated with dissociable patterns of at-rest neural activity.

Indexed as

Alpha RhythmRestAdolescentAdultAnalysis of VarianceAutistic DisorderBrainElectroencephalographyFemaleHumansMaleMiddle AgedQuantitative Trait, HeritableSurveys and QuestionnairesYoung Adult

Identifiers

PMID30097597
PMCPMC6086866

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.