ArticleNature communications2018
Growth tradeoffs produce complex microbial communities on a single limiting resource.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Cross-feeding enables robust coexistence between four bacterial species.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Co-targeting Metabolic Neighbours Constraints Bacterial Adaptive Evolution.bioRxiv : the preprint server for biology · 2026Article
- Population dynamics of generalist and specialist strategies under feast-famine cycles.PLoS computational biology · 2026Article
- Community state shifts driven by total carbon availability over resource complexity in a synthetic microbial community.ISME communications · 2026Article
- Bacterial community dynamics as a result of growth-yield trade-off and multispecies metabolic interactions toward understanding the gut biofilm niche.BMC microbiology · 2024Article
- Substrate complexity buffers negative interactions in a synthetic community of leaf litter degraders.FEMS microbiology ecology · 2024Article
- Quantifying massively parallel microbial growth with spatially mediated interactions.PLoS computational biology · 2024Article
- Biodiversity is enhanced by sequential resource utilization and environmental fluctuations via emergent temporal niches.PLoS computational biology · 2024Article
- Horizontal gene transfer is predicted to overcome the diversity limit of competing microbial species.Nature communications · 2024Article
- Minorities drive growth resumption in cross-feeding microbial communities.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Antibiotic-degrading resistance changes bacterial community structure via species-specific responses.The ISME journal · 2023Article
- Understanding cellular growth strategies via optimal control.Journal of the Royal Society, Interface · 2023Article
- Diauxic lags explain unexpected coexistence in multi-resource environments.Molecular systems biology · 2022Article
- Dynamic proteome allocation regulates the profile of interaction of auxotrophic bacterial consortia.Royal Society open science · 2022Article
- Article
- Transposable elements promote the evolution of genome streamlining.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Correlated chromosomal periodicities according to the growth rate and gene expression.Scientific reports · 2020Article
- Evolution of Microbial Growth Traits Under Serial Dilution.Genetics · 2020Article
- Dynamic metabolic adaptation can promote species coexistence in competitive microbial communities.PLoS computational biology · 2020Article
- Trusting the hand that feeds: microbes evolve to anticipate a serial transfer protocol as individuals or collectives.BMC evolutionary biology · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The relationship between the dynamics of a community and its constituent pairwise interactions is a fundamental problem in ecology. Higher-order ecological effects beyond pairwise interactions may be key to complex ecosystems, but mechanisms to produce these effects remain poorly understood. Here we model microbial growth and competition to show that higher-order effects can arise from variation in multiple microbial growth traits, such as lag times and growth rates, on a single limiting resource with no other interactions. These effects produce a range of ecological phenomena: an unlimited number of strains can exhibit multistability and neutral coexistence, potentially with a single keystone strain; strains that coexist in pairs do not coexist all together; and a strain that wins all pairwise competitions can go extinct in a mixed competition. Since variation in multiple growth traits is ubiquitous in microbial populations, our results indicate these higher-order effects may also be widespread, especially in laboratory ecology and evolution experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.