Evidence map›Paper›PMID 30097530›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

Nucleotide Composition of Human Ig Nontemplated Regions Depends on Trimming of the Flanking Gene Segments, and Terminal Deoxynucleotidyl Transferase Favors Adding Cytosine, Not Guanosine, in Most VDJ Rearrangements.

Tina Funck, Mike Bogetofte Barnkob, Nanna Holm, Line Ohm-Laursen, Camilla Slot Mehlum, Sören Möller, Torben Barington

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Tina FunckDepartment of Clinical Biochemistry, Zealand University Hospital, Roskilde 4000, Denmark.ORCID 0000-0002-1211-9565
Mike Bogetofte BarnkobDepartment of Clinical Immunology, Odense University Hospital, Odense 5000, Denmark.ORCID 0000-0002-5892-1174
Nanna HolmDepartment of Clinical Immunology, Odense University Hospital, Odense 5000, Denmark.
Line Ohm-LaursenRandall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, King's College London, London SE1 1UL, United Kingdom.
Camilla Slot MehlumDepartment of Otorhinolaryngology-Head and Neck Surgery, Odense University Hospital, Odense 5000, Denmark.ORCID 0000-0002-5740-612X
Sören MöllerOPEN, Odense Patient Data Explorative Network, Odense University Hospital, Odense 5000, Denmark; and.ORCID 0000-0003-0858-4269
Torben BaringtonDepartment of Clinical Immunology, Odense University Hospital, Odense 5000, Denmark; barington@dadlnet.dk.ORCID 0000-0001-6968-148X
Odense University Hospital · DKUniversity of Southern Denmark · DKKing's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The formation of nontemplated (N) regions during Ig gene rearrangement is a major contributor to Ab diversity. To gain insights into the mechanisms behind this, we studied the nucleotide composition of N regions within 29,962 unique human V

Indexed as

Gene Rearrangement, B-Lymphocyte, Heavy ChainImmunoglobulin Heavy ChainsImmunoglobulin Variable RegionAdolescentAdultChildChild, PreschoolCytosineDNA NucleotidylexotransferaseFemaleGuanosineHumansMaleCytosineDNA NucleotidylexotransferaseGuanosineImmunoglobulin Heavy ChainsImmunoglobulin Variable Region

Identifiers

PMID30097530
PMCPMC6121214
OpenAlexW2886984647

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.