Evidence map›Paper›PMID 30097511›Full record

ReviewJournal of lipid research2019

Determinants of body fat distribution in humans may provide insight about obesity-related health risks.

Aaron P Frank, Roberta de Souza Santos, Biff F Palmer, Deborah J Clegg

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of lipid research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 179 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
179citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

179 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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119 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aaron P FrankDiabetes, Obesity, and Wellness Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
Roberta de Souza SantosDiabetes, Obesity, and Wellness Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
Biff F PalmerDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
Deborah J CleggDiabetes, Obesity, and Wellness Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA Deborah.clegg@cshs.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity increases the risks of developing cardiovascular and metabolic diseases and degrades quality of life, ultimately increasing the risk of death. However, not all forms of obesity are equally dangerous: some individuals, despite higher percentages of body fat, are at less risk for certain chronic obesity-related complications. Many open questions remain about why this occurs. Data suggest that the physical location of fat and the overall health of fat dramatically influence disease risk; for example, higher concentrations of visceral relative to subcutaneous adipose tissue are associated with greater metabolic risks. As such, understanding the determinants of the location and health of adipose tissue can provide insight about the pathological consequences of obesity and can begin to outline targets for novel therapeutic approaches to combat the obesity epidemic. Although age and sex hormones clearly play roles in fat distribution and location, much remains unknown about gene regulation at the level of adipose tissue or how genetic variants regulate fat distribution. In this review, we discuss what is known about the determinants of body fat distribution, and we highlight the important roles of sex hormones, aging, and genetic variation in the determination of body fat distribution and its contribution to obesity-related comorbidities.

Indexed as

HealthAdipose TissueGenetic VariationGonadal Steroid HormonesHumansObesityRiskGonadal Steroid Hormonesadipose tissueagingepigeneticsestrogengeneticssex chromosomestestosterone

Identifiers

PMID30097511
PMCPMC6795075

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.