Evidence map›Paper›PMID 30097497›Full record

ArticleClinical chemistry2018

Discovery and Validation of Salivary Extracellular RNA Biomarkers for Noninvasive Detection of Gastric Cancer.

Feng Li, Janice M Yoshizawa, Kyoung-Mee Kim, Julie Kanjanapangka, Tristan R Grogan, Xiaoyan Wang, David E Elashoff, Shigeo Ishikawa, David Chia, Wei Liao and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Review
  7. Observational
  8. Review
  9. Review
  10. Extracellular RNAs as Messengers and Early Biomarkers in Neurodegeneration.International journal of molecular sciences · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Integrating Salivary Biomarkers CST4 andClinical Medicine Insights. Oncology · 2025
    Article
  17. Article
  18. Review
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Feng LiInstitute of Diagnostic in Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Janice M YoshizawaSchool of Dentistry, University of California, Los Angeles, CA.
Kyoung-Mee KimDepartment of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Julie KanjanapangkaSchool of Dentistry, University of California, Los Angeles, CA.
Tristan R GroganDepartment of Medicine Statistics Core, David Geffen School of Medicine, University of California, Los Angeles, CA.
Xiaoyan WangDepartment of Medicine Statistics Core, David Geffen School of Medicine, University of California, Los Angeles, CA.
David E ElashoffDepartment of Medicine Statistics Core, David Geffen School of Medicine, University of California, Los Angeles, CA.
Shigeo IshikawaSchool of Dentistry, University of California, Los Angeles, CA.
David ChiaDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.
Wei LiaoSchool of Dentistry, University of California, Los Angeles, CA.
David AkinSchool of Dentistry, University of California, Los Angeles, CA.
Xinmin YanSchool of Dentistry, University of California, Los Angeles, CA.
Min-Sun LeeDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Rayun ChoiDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Su-Mi KimDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
So-Young KangDepartment of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Jae-Moon BaeDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Tae-Sung SohnDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Jun-Ho LeeDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Min-Gew ChoiDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Byung-Hoon MinDepartment of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Jun-Haeng LeeDepartment of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Jae J KimDepartment of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Yong KimSchool of Dentistry, University of California, Los Angeles, CA; dtww@ucla.edu thadyk@ucla.edu sungkimm@skku.edu.
Sung KimDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; dtww@ucla.edu thadyk@ucla.edu sungkimm@skku.edu.
David T W WongSchool of Dentistry, University of California, Los Angeles, CA; dtww@ucla.edu thadyk@ucla.edu sungkimm@skku.edu.

Funding

UCLA FUNDAMENTAL CLINICAL RESEARCH TRAINING PROGRAMT32DE007296 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 1996 to 2011
$5.8M
Clinical Utility of Salivary ExRNA Biomarkers for Gastric Cancer DetectionUH3TR000923 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2015 to 2017
$2.7M
Advancing EFIRM-Liquid Biopsy (eLB) to a CLIA-Certified Laboratory Developed Test (eLB-LDT) for Detection of Actionable EGFR Mutations in NSCLC PatientsUH2CA206126 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHIA, DAVID S., DAS, KINGSHUK · 2017 to 2018
$368k
NCATS NIH HHS UH3 TR000923NCI NIH HHS UH2 CA206126NIDCR NIH HHS T32 DE007296
6 · The paper itself

Abstract

backgroundBiomarkers are needed for noninvasive early detection of gastric cancer (GC). We investigated salivary extracellular RNA (exRNA) biomarkers as potential clinical evaluation tools for GC.

methodsUnstimulated whole saliva samples were prospectively collected from 294 individuals (163 GC and 131 non-GC patients) who underwent endoscopic evaluation at the Samsung Medical Center in Korea. Salivary transcriptomes of 63 GC and 31 non-GC patients were profiled, and mRNA biomarker candidates were verified with reverse transcription quantitative real-time PCR (RT-qPCR). In parallel, microRNA (miRNA) biomarkers were profiled and verified with saliva samples from 10 GC and 10 non-GC patients. Candidate biomarkers were validated with RT-qPCR in an independent cohort of 100/100 saliva samples from GC and non-GC patients. Validated individual markers were configured into a best performance panel.

resultsWe identified 30 mRNA and 15 miRNA candidates whose expression pattern associated with the presence of GC. Among them, 12 mRNA and 6 miRNA candidates were verified with the discovery cohort by RT-qPCR and further validated with the independent cohort (n = 200). The configured biomarker panel consisted of 3 mRNAs (

conclusionsWe have discovered and validated a panel of salivary exRNA biomarkers with credible clinical performance for the detection of GC. Our study demonstrates the potential utility of salivary exRNA biomarkers in screening and risk assessment for GC.

Indexed as

Gene Expression Regulation, NeoplasticBiomarkers, TumorCase-Control StudiesCohort StudiesGene Expression ProfilingHumansMicroarray AnalysisMicroRNAsProspective StudiesReproducibility of ResultsRNA, MessengerROC CurveSalivaSensitivity and SpecificityStomach NeoplasmsTranscriptomeBiomarkers, TumorMicroRNAsRNA, Messenger

Identifiers

PMID30097497
PMCPMC7720197

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.