ArticleNeurology2018
Selective D2 receptor PET in manganese-exposed workers.
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Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
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Who cites it
21 citing papers in PubMed.
- Case report: Recurring and treatment-resistant depression in acquired hepatocerebral degeneration due to a congenital portosystemic shunt.Frontiers in psychiatry · 2024Article
- Consequences of Disturbing Manganese Homeostasis.International journal of molecular sciences · 2023Review
- Neuroinflammation and white matter alterations in occupational manganese exposure assessed by diffusion basis spectrum imaging.Neurotoxicology · 2023Article
- Environmental manganese exposure and cognitive control in a South African population.Neurotoxicology · 2022Article
- Review
- Principal Component Analysis of Striatal and Extrastriatal D2 Dopamine Receptor Positron Emission Tomography in Manganese-Exposed Workers.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Depression and anxiety in a manganese-exposed community.Neurotoxicology · 2021Article
- Evaluating the risk of manganese-induced neurotoxicity of parenteral nutrition: review of the current literature.Expert opinion on drug metabolism & toxicology · 2021Review
- Molecular Targets of Manganese-Induced Neurotoxicity: A Five-Year Update.International journal of molecular sciences · 2021Review
- Nigral MRI features of asymptomatic welders.Parkinsonism & related disorders · 2021Article
- Severity of parkinsonism associated with environmental manganese exposure.Environmental health : a global access science source · 2021Article
- Review
- A Rapid Motor Task-Based Screening Tool for Parkinsonism in Community-Based Studies.Frontiers in neurology · 2021Article
- Manganese-induced neurodegenerative diseases and possible therapeutic approaches.Expert review of neurotherapeutics · 2020Review
- [11C]dihydrotetrabenazine Positron Emission Tomography in Manganese-Exposed Workers.Journal of occupational and environmental medicine · 2020Article
- NF-κB Signaling in Astrocytes Modulates Brain Inflammation and Neuronal Injury Following Sequential Exposure to Manganese and MPTP During Development and Aging.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Brain manganese and the balance between essential roles and neurotoxicity.The Journal of biological chemistry · 2020Review
- Manganese exposure, parkinsonian signs, and quality of life in South African mine workers.American journal of industrial medicine · 2020Article
- New Insights on the Role of Manganese in Alzheimer's Disease and Parkinson's Disease.International journal of environmental research and public health · 2019Review
- MRI Signal Intensity and Parkinsonism in Manganese-Exposed Workers.Journal of occupational and environmental medicine · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Susan R CriswellFrom the Department of Neurology (S.R.C., M.N.W., S.S.N., J.S.P., J.L.-K., B.A.R.), Department of Radiology (J.S.P., S.M.M.), Department of Neuroscience (J.S.P.), Program in Physical Therapy (J.S.P.), Program in Occupational Therapy (J.S.P.), and Department of Biochemistry and Molecular Biophysics (S.M.M.), Washington University School of Medicine, St. Louis, MO; Department of Environmental and Occupational Health Sciences (L.S.) and Department of Biostatistics (L.S.), University of Washington, School of Public Health, Seattle; Department of Family Medicine and Public Health (H.C.) and Department of Neurosciences (H.C.), University of California, San Diego, School of Medicine, La Jolla; and School of Public Health (B.A.R.), Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa.
Mark N WardenFrom the Department of Neurology (S.R.C., M.N.W., S.S.N., J.S.P., J.L.-K., B.A.R.), Department of Radiology (J.S.P., S.M.M.), Department of Neuroscience (J.S.P.), Program in Physical Therapy (J.S.P.), Program in Occupational Therapy (J.S.P.), and Department of Biochemistry and Molecular Biophysics (S.M.M.), Washington University School of Medicine, St. Louis, MO; Department of Environmental and Occupational Health Sciences (L.S.) and Department of Biostatistics (L.S.), University of Washington, School of Public Health, Seattle; Department of Family Medicine and Public Health (H.C.) and Department of Neurosciences (H.C.), University of California, San Diego, School of Medicine, La Jolla; and School of Public Health (B.A.R.), Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa.
Susan Searles NielsenFrom the Department of Neurology (S.R.C., M.N.W., S.S.N., J.S.P., J.L.-K., B.A.R.), Department of Radiology (J.S.P., S.M.M.), Department of Neuroscience (J.S.P.), Program in Physical Therapy (J.S.P.), Program in Occupational Therapy (J.S.P.), and Department of Biochemistry and Molecular Biophysics (S.M.M.), Washington University School of Medicine, St. Louis, MO; Department of Environmental and Occupational Health Sciences (L.S.) and Department of Biostatistics (L.S.), University of Washington, School of Public Health, Seattle; Department of Family Medicine and Public Health (H.C.) and Department of Neurosciences (H.C.), University of California, San Diego, School of Medicine, La Jolla; and School of Public Health (B.A.R.), Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa.
Joel S PerlmutterFrom the Department of Neurology (S.R.C., M.N.W., S.S.N., J.S.P., J.L.-K., B.A.R.), Department of Radiology (J.S.P., S.M.M.), Department of Neuroscience (J.S.P.), Program in Physical Therapy (J.S.P.), Program in Occupational Therapy (J.S.P.), and Department of Biochemistry and Molecular Biophysics (S.M.M.), Washington University School of Medicine, St. Louis, MO; Department of Environmental and Occupational Health Sciences (L.S.) and Department of Biostatistics (L.S.), University of Washington, School of Public Health, Seattle; Department of Family Medicine and Public Health (H.C.) and Department of Neurosciences (H.C.), University of California, San Diego, School of Medicine, La Jolla; and School of Public Health (B.A.R.), Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa.
Stephen M MoerleinFrom the Department of Neurology (S.R.C., M.N.W., S.S.N., J.S.P., J.L.-K., B.A.R.), Department of Radiology (J.S.P., S.M.M.), Department of Neuroscience (J.S.P.), Program in Physical Therapy (J.S.P.), Program in Occupational Therapy (J.S.P.), and Department of Biochemistry and Molecular Biophysics (S.M.M.), Washington University School of Medicine, St. Louis, MO; Department of Environmental and Occupational Health Sciences (L.S.) and Department of Biostatistics (L.S.), University of Washington, School of Public Health, Seattle; Department of Family Medicine and Public Health (H.C.) and Department of Neurosciences (H.C.), University of California, San Diego, School of Medicine, La Jolla; and School of Public Health (B.A.R.), Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa.
Lianne SheppardFrom the Department of Neurology (S.R.C., M.N.W., S.S.N., J.S.P., J.L.-K., B.A.R.), Department of Radiology (J.S.P., S.M.M.), Department of Neuroscience (J.S.P.), Program in Physical Therapy (J.S.P.), Program in Occupational Therapy (J.S.P.), and Department of Biochemistry and Molecular Biophysics (S.M.M.), Washington University School of Medicine, St. Louis, MO; Department of Environmental and Occupational Health Sciences (L.S.) and Department of Biostatistics (L.S.), University of Washington, School of Public Health, Seattle; Department of Family Medicine and Public Health (H.C.) and Department of Neurosciences (H.C.), University of California, San Diego, School of Medicine, La Jolla; and School of Public Health (B.A.R.), Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa.
Jason Lenox-KrugFrom the Department of Neurology (S.R.C., M.N.W., S.S.N., J.S.P., J.L.-K., B.A.R.), Department of Radiology (J.S.P., S.M.M.), Department of Neuroscience (J.S.P.), Program in Physical Therapy (J.S.P.), Program in Occupational Therapy (J.S.P.), and Department of Biochemistry and Molecular Biophysics (S.M.M.), Washington University School of Medicine, St. Louis, MO; Department of Environmental and Occupational Health Sciences (L.S.) and Department of Biostatistics (L.S.), University of Washington, School of Public Health, Seattle; Department of Family Medicine and Public Health (H.C.) and Department of Neurosciences (H.C.), University of California, San Diego, School of Medicine, La Jolla; and School of Public Health (B.A.R.), Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa.
Harvey CheckowayFrom the Department of Neurology (S.R.C., M.N.W., S.S.N., J.S.P., J.L.-K., B.A.R.), Department of Radiology (J.S.P., S.M.M.), Department of Neuroscience (J.S.P.), Program in Physical Therapy (J.S.P.), Program in Occupational Therapy (J.S.P.), and Department of Biochemistry and Molecular Biophysics (S.M.M.), Washington University School of Medicine, St. Louis, MO; Department of Environmental and Occupational Health Sciences (L.S.) and Department of Biostatistics (L.S.), University of Washington, School of Public Health, Seattle; Department of Family Medicine and Public Health (H.C.) and Department of Neurosciences (H.C.), University of California, San Diego, School of Medicine, La Jolla; and School of Public Health (B.A.R.), Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa.
Brad A RacetteFrom the Department of Neurology (S.R.C., M.N.W., S.S.N., J.S.P., J.L.-K., B.A.R.), Department of Radiology (J.S.P., S.M.M.), Department of Neuroscience (J.S.P.), Program in Physical Therapy (J.S.P.), Program in Occupational Therapy (J.S.P.), and Department of Biochemistry and Molecular Biophysics (S.M.M.), Washington University School of Medicine, St. Louis, MO; Department of Environmental and Occupational Health Sciences (L.S.) and Department of Biostatistics (L.S.), University of Washington, School of Public Health, Seattle; Department of Family Medicine and Public Health (H.C.) and Department of Neurosciences (H.C.), University of California, San Diego, School of Medicine, La Jolla; and School of Public Health (B.A.R.), Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa. racetteb@wustl.edu.
Funding
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWILDLIFE BIOMARKER APPLICATIONS TO REMEDIATION DECISION MAKINGP42ES004696 · NIEHS · UNIVERSITY OF WASHINGTON · PI NEUMANN, REBECCA B · 1987 to 2021
$51.2MWashington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4MUniversity of Washington Education and Research CenterT42OH008433 · OH · UNIVERSITY OF WASHINGTON · PI SIMPSON, CHRISTOPHER D · 2005 to 2024
$29.4MThe ESPINA Study Follow-up Examination in 2016: Environmental Pollutants and Child/Adolescent DevelopmentR01ES025792 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Raeanne Cristine Moore, Jose Ricardo Suarez · 2016 to 2026
$5.6MImaging Biomarkers of Neurotoxicity in WeldersR01ES021488 · NIEHS · WASHINGTON UNIVERSITY · PI Brad A Racette · 2013 to 2026
$5.3MMotor and Cognitive Health Outcomes in a Mn-Exposed African CommunityR01ES025991 · NIEHS · WASHINGTON UNIVERSITY · PI RACETTE, BRAD A · 2015 to 2019
$3.7MEpidemiology of Parkinsonism in WeldersR01ES013743 · NIEHS · WASHINGTON UNIVERSITY · PI RACETTE, BRAD A · 2007 to 2011
$2.6MEpidemiology and Biomarkers of Parkinsonism in WeldersK24ES017765 · NIEHS · WASHINGTON UNIVERSITY · PI RACETTE, BRAD A · 2009 to 2018
$1.5MRESTING STATE FUNCTIONAL CONNECTIVITY MRI IN MANGANESE EXPOSED WELDERSK23ES021444 · NIEHS · WASHINGTON UNIVERSITY · PI CRISWELL, SUSAN · 2012 to 2016
$809kPesticides and Mental Health among Adolescents in Ecuadorian Agricultural CommunitiesR21ES026084 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUAREZ, JOSE RICARDO · 2015 to 2016
$344kNCATS NIH HHS UL1 TR002345NCRR NIH HHS UL1 RR024992NIEHS NIH HHS K23 ES021444NIEHS NIH HHS K24 ES017765NIEHS NIH HHS P42 ES004696NIEHS NIH HHS R01 ES013743NIEHS NIH HHS R01 ES021488NIEHS NIH HHS R01 ES025792NIEHS NIH HHS R01 ES025991NIEHS NIH HHS R21 ES026084NIOSH CDC HHS T42 OH008433
Abstract
objectiveTo investigate the associations between manganese (Mn) exposure, D2 dopamine receptors (D2Rs), and parkinsonism using [
methodsWe used NMB PET to evaluate 50 workers with a range of Mn exposure: 22 Mn-exposed welders, 15 Mn-exposed workers, and 13 nonexposed workers. Cumulative Mn exposure was estimated from work histories, and movement disorder specialists examined all workers. We calculated NMB D2R nondisplaceable binding potential (BPND) for the striatum, globus pallidus, thalamus, and substantia nigra (SN). Multivariate analysis of covariance with post hoc descriptive discriminate analysis identified regional differences by exposure group. We used linear regression to examine the association among Mn exposure, Unified Parkinson's Disease Rating Scale motor subsection 3 (UPDRS3) score, and regional D2R BPND.
resultsD2R BPND in the SN had the greatest discriminant power among exposure groups ( CONCLUSIONS AND RELEVANCE: Nigral D2R BPND increased with Mn exposure and clinical parkinsonism, indicating dose-dependent dopaminergic dysfunction of the SN in Mn neurotoxicity.
Indexed as
AdultAgedBenperidolBrainCase-Control StudiesFemaleHumansMaleManganeseManganese PoisoningMiddle AgedMultimodal ImagingNeuroimagingParkinsonian DisordersPositron-Emission TomographyReceptors, Dopamine D2(11C)(N-methyl)benperidolBenperidolManganeseReceptors, Dopamine D2
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