GuidelineBMJ (Clinical research ed.)2018
Corticosteroid therapy for sepsis: a clinical practice guideline.
2 registry-linked trialsOpen access · hybridAbstract readPractice Guideline
In one paragraph
Guideline in BMJ (Clinical research ed.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 62 papers, 10 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 10 pooled it
11.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicentre Concealed-Allocation Multi-arms Blinded Randomized Controlled Trial to Identify the Best Sepsis Population for Corticotherapy
NCT04540926 phase1 / phase2unknown statusnot on this mapstarted 2020, after this paper: background citation
Utility of Low Doses of Corticosteroids and Cyclosporine Combined With Enoxaparin, in Patients With COVID-19 Pneumonia at the ISSSTE Regional Hospital, Puebla, During the Contingency Period Due to the SARS-Cov2 Pandemic
Who cites it
62 citing papers in PubMed, 10 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- Continuous versus Intermittent Hydrocortisone for the Treatment of Septic Shock: A Systematic Review and Meta-Analysis.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Pooled it
- Corticosteroids for sepsis and septic shock: a meta-analysis of 18 RCTs with dose-stratified and fludrocortisone subgroup evaluation.BMC anesthesiology · 2025Pooled it
- Corticosteroids for treating sepsis in children and adults.The Cochrane database of systematic reviews · 2025Pooled it
- Research trends and hotspots on septic shock: a bibliometric study and visualization analysis.Frontiers in medicine · 2024Pooled it
- Pooled it
- Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19).Intensive care medicine · 2020Guideline
- Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children.Intensive care medicine · 2020Guideline
- Corticosteroids for treating sepsis in children and adults.The Cochrane database of systematic reviews · 2019Pooled it
- Corticosteroids as adjunctive therapy in the treatment of influenza.The Cochrane database of systematic reviews · 2019Pooled it
- Impact and Beneficial Critical Points of Clinical Outcome in Corticosteroid Management of Adult Patients With Sepsis: Meta-Analysis and GRADE Assessment.Frontiers in pharmacology · 2019Pooled it
- Cyclosporine A plus low-dose steroid treatment in COVID-19 improves clinical outcomes in patients with moderate to severe disease: A pilot study.Journal of internal medicine · 2021Trial
- The cost-effectiveness of adjunctive corticosteroids for patients with septic shock.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2020Trial
- Lymphopenia and elevated NLR identify patients with septic shock who may benefit from corticosteroids: a target trial emulation study.Intensive care medicine experimental · 2026Article
- Caffeic Acid Modulates Protein Disulfide Isomerase-NLRP3 Inflammasome Signaling to Mitigate Inflammation in Acute Pneumonia.International journal of biological sciences · 2026Article
- Oral Treatment with the Vimentin-Targeting Compound ALD-R491 Mitigates Hyperinflammation, Multi-Organ Injury, and Mortality in CLP-Induced Septic Mice.Life (Basel, Switzerland) · 2025Article
- Multicenter target trial emulation to evaluate corticosteroids for sepsis stratified by predicted organ dysfunction trajectory.Nature communications · 2025Article
- Review
- Article
- Hydrocortisone treatment is associated with early recovery from severe septic shock in patients with obstructive pyelonephritis due to upper urinary tract stone.BJUI compass · 2025Article
- Influence of hydrocortisone infusion method on the clinical outcome of patients with septic shock: A systematic review and meta-analysis.Journal of intensive medicine · 2025Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 19 institutions in 11 countries.
Francois LamontagneDepartment of Medicine, Université de Sherbrooke, Sherbrooke, Canada.
Bram RochwergDepartment of Medicine, McMaster University, Hamilton, Canada.
Lyubov LytvynDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
Gordon H GuyattDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
Morten Hylander MøllerDepartment of Intensive Care, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Djillali AnnaneService de Médecine Intensive et Réanimation, Hôpital Raymond Poincaré, Garches, France.
Michelle E KhoSchool of Rehabilitation Science, McMaster University, Hamilton, Canada.
Neill K J AdhikariDepartment of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto Canada.
Flavia MachadoFederal University of Sao Paulo, Sao Paulo, Brazil.
Per O VandvikInstitute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway.
Peter DodekCenter for Health Evaluation and Outcome Sciences and Division of Critical Care Medicine, St Paul's Hospital and University of British Columbia, Vancouver, Canada.
Rebecca LeboeufDepartment of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, Canada.
Matthias BrielDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
Madiha HashmiDepartment of Anaesthesiology, Aga Khan University, Karachi, Pakistan.
Julie CamsooksaiPoole Hospital NHS Foundation Trust, Dorset, United Kingdom.
Manu Shankar-HariGuy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Mahder Kinfe BarakiDepartment of Anesthesiology, Addis Ababa University, Addis Ababa, Ethiopia.
Karie FugateRenton, USA.
Shunjie ChuaCarevise Mexico, Mexico City, Mexico.
Christophe MartiDivision of General Internal Medicine, Rehabilitation and Geriatrics, University Hospitals of Geneva, Geneva, Switzerland.
Dian CohenCentre de santé de la vallée Massawippi, Ayer's Cliff, Canada.
Edouard BottonComité stratégique patient-partenaire, Centre de recherche du CHU de Sherbrooke, Centre intégré universitaire de santé et de services sociaux - Estrie, Sherbrooke, Canada.
Thomas AgoritsasDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
Reed A C SiemieniukDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada reed.siemieniuk@medportal.ca.
McMaster University · CAImpact · CAUniversity Hospital of Geneva · CHAddis Ababa University · ETAga Khan University · PKCentre Hospitalier de l’Université de Montréal · CACentre Hospitalier Universitaire de Sherbrooke · CACopenhagen University Hospital · DKHôpital Raymond-Poincaré · FRInformation Group on Reproductive Choice · MXInnlandet Hospital Trust · NOKing's College London · GBLatin American Sepsis Institute · BRPoole Hospital · GBRenton Technical College · USSunnybrook Health Science Centre · CAUniversité de Sherbrooke · CAUniversity of Basel · CHUniversity of British Columbia · CA
Funding
Department of Health 16/33/01Department of Health CS-2016-16-011Department of Health EME/16/33/01
Abstract
PubMed holds no abstract for this paper.
Indexed as
Guideline AdherenceAdrenal Cortex HormonesClinical Decision-MakingEvidence-Based MedicineHumansSepsisAdrenal Cortex Hormones
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
NCT04280497ClinicalTrials.gov
NCT04540926ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.