Evidence map›Paper›PMID 30097458›Full record

ArticleJournal of the American Society of Nephrology : JASN2018

Mechanism of Fibrosis in

Siu Chiu Chan, Ying Zhang, Annie Shao, Svetlana Avdulov, Jeremy Herrera, Karam Aboudehen, Marco Pontoglio, Peter Igarashi

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 100 citations in OpenAlex.

  1. Article
  2. Glis3 Is a Modifier of Cyst Progression in Autosomal Dominant Polycystic Kidney Disease.Journal of the American Society of Nephrology : JASN · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Siu Chiu ChanDepartment of Medicine and.
Ying ZhangMinnesota Supercomputing Institute, University of Minnesota, Minneapolis, Minnesota; and.
Annie ShaoDepartment of Medicine and.
Svetlana AvdulovDepartment of Medicine and.
Jeremy HerreraDepartment of Medicine and.
Karam AboudehenDepartment of Medicine and.
Marco PontoglioDepartment of Development, Reproduction and Cancer, Institut Cochin, Institut National de la Santé et de la Recherche Médicale U1016/Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Université Paris-Descartes, Paris, France.
Peter IgarashiDepartment of Medicine and igarashi@umn.edu.ORCID 0000-0001-8698-1185
Helmholtz Institute Jena · DEInserm · FROffice of Basic Energy Sciences · US

Funding

REGULATION OF RENAL NA+/H+ EXCHANGER GENE EXPRESSIONR01DK042921 · NIDDK · YALE UNIVERSITY · PI IGARASHI, PETER · 1991 to 2025
$5.1M
Regulation of Kidney-Specific Gene ExpressionR37DK042921 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI IGARASHI, PETER · 2011 to 2020
$3.6M
NIDDK NIH HHS R01 DK042921NIDDK NIH HHS R37 DK042921
6 · The paper itself

Abstract

backgroundMutation of

methodsTo explore the mechanism of fibrosis, we created HNF-1

resultsThe HNF-1

conclusionsAblation of HNF-1

Indexed as

AnimalsCell LineCell LineageDisease Models, AnimalEpithelial-Mesenchymal TransitionFemaleFibrosisGenes, DominantGoutHepatocyte Nuclear Factor 1-betaHumansHyperuricemiaKidneyKidney DiseasesMaleMiceHepatocyte Nuclear Factor 1-betaHNF1B protein, humanHnf1b protein, mouseRepressor ProteinsTransforming Growth Factor betaTwist2 protein, mouseTwist-Related Protein 1cystic kidneygenetic renal diseasegene transcriptionrenal fibrosistranscription factors

Identifiers

PMID30097458
PMCPMC6171276
OpenAlexW2887346116

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.