Trial reportBMC nephrology2018
Effect of haemodiafiltration vs conventional haemodialysis on growth and cardiovascular outcomes in children - the HDF, heart and height (3H) study.
Trial report in BMC nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02063776 (The Effects of Haemodiafiltration), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Haemodiafiltration (HDF) vs Conventional Haemodialysis (HD) on Growth and Cardiovascular Markers in Children - 3H (HDF, Hearts and Height) Study
Who cites it
21 citing papers in PubMed.
- Online hemodiafilteration use in children: a single center experience with a twist.BMC nephrology · 2020Trial
- Dialysis-associated cardiovascular disease risk in children: mechanism and management.Pediatric nephrology (Berlin, Germany) · 2026Review
- Comparing outcomes with different dialysis modalities in children with kidney failure: home hemodialysis versus in-center hemodiafiltration or conventional hemodialysis.Pediatric nephrology (Berlin, Germany) · 2026Article
- Haemodiafiltration versus high-flux haemodialysis-a Consensus Statement from the EuDial Working Group of the ERA.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- Monitoring and maintaining quality in the paediatric haemodialysis unit.Pediatric nephrology (Berlin, Germany) · 2025Review
- Cost Analysis of End-Stage Renal Disease in Pediatric Patients in Greece.Healthcare (Basel, Switzerland) · 2024Article
- Hemodiafiltration for children with stage 5 chronic kidney disease: technical aspects and outcomes.Pediatric nephrology (Berlin, Germany) · 2024Review
- Changes in the cardiovascular risk profile in children approaching kidney replacement therapy.EClinicalMedicine · 2024Article
- Indoxyl Sulfate Contributes to Impaired Height Velocity in (Pre)School Children.Kidney international reports · 2024Article
- Review
- The effects of hospital and dialysis unit characteristics on hospitalizations for access-related complications among children on maintenance dialysis: a European, multicenter, observational, cross-sectional study.Pediatric nephrology (Berlin, Germany) · 2023Article
- Hemodiafiltration Is Associated With Reduced Inflammation and Increased Bone Formation Compared With Conventional Hemodialysis in Children: The HDF, Hearts and Heights (3H) Study.Kidney international reports · 2021Article
- Hemodiafiltration maintains a sustained improvement in blood pressure compared to conventional hemodialysis in children-the HDF, heart and height (3H) study.Pediatric nephrology (Berlin, Germany) · 2021Observational
- Reducing the burden of cardiovascular disease in children with chronic kidney disease: prevention vs. damage limitation.Pediatric nephrology (Berlin, Germany) · 2021Review
- Plasma pseudouridine levels reflect body size in children on hemodialysis.Pediatric nephrology (Berlin, Germany) · 2020Article
- Cardiovascular risk factors in children on dialysis: an update.Pediatric nephrology (Berlin, Germany) · 2020Review
- Nephrology and Public Policy Committee propositions to stimulate research collaboration in adults and children in Europe.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2019Article
- Haemodiafiltration use in children: data from the Italian Pediatric Dialysis Registry.Pediatric nephrology (Berlin, Germany) · 2019Article
- Uremic Toxin Concentrations are Related to Residual Kidney Function in the Pediatric Hemodialysis Population.Toxins · 2019Article
- Effects of Hemodiafiltration versus Conventional Hemodialysis in Children with ESKD: The HDF, Heart and Height Study.Journal of the American Society of Nephrology : JASN · 2019Observational
Corrections and comments
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Authors and funding
41 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiovascular disease is prevalent in children on dialysis and accounts for almost 30% of all deaths. Randomised trials in adults suggest that haemodiafiltration (HDF) with high convection volumes is associated with reduced cardiovascular mortality compared to high-flux haemodialysis (HD); however paediatric data are scarce. We designed the haemodiafiltration, heart and height (3H) study to test the hypothesis that children on HDF have an improved cardiovascular risk profile, growth and nutritional status and quality of life, compared to those on conventional HD. We performed a non-randomised parallel-arm intervention study within the International Paediatric Haemodialysis Network Registry comparing children on HDF and conventional HD to determine annualised change in cardiovascular end-points and growth. Here we present the 3H study design and baseline characteristics of the study population.
methods190 children were screened and 177 (106 on HD and 71 on HDF) recruited from 28 centres in 10 countries. There was no difference in age, underlying diagnosis, comorbidities, previous dialysis therapy, dialysis vintage, residual renal function, type of vascular access or blood flow between HD and HDF groups. High flux dialysers were used in 63% of HD patients and ultra-pure water was available in 52%. HDF patients achieved a median convection volume of 13.3 L/m DISCUSSION: This is the largest study on dialysis outcomes in children that involves deep phenotyping across a wide range of cardiovascular, anthropometric, nutritional and health-related quality of life measures, to test the hypothesis that HDF leads to improved cardiovascular and growth outcomes compared to conventional HD.
trial registrationClinicalTrials.gov: NCT02063776 . The trial was prospectively registered on the 14 Feb 2014.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.