Trial reportParticle and fibre toxicology2018
Cardiovascular and inflammatory mechanisms in healthy humans exposed to air pollution in the vicinity of a steel mill.
Trial report in Particle and fibre toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Dysregulated blood biomarkers in women with acute and chronic respiratory conditions due to air pollutant exposure: An exploratory systematic review.Journal of global health · 2024Pooled it
- The short- and long-term associations of particulate matter with inflammation and blood coagulation markers: A meta-analysis.Environmental pollution (Barking, Essex : 1987) · 2020Pooled it
- Association between exposure to air pollution and arterial stiffness in participants with and without atherosclerotic cardiovascular disease.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Short-Term and Long-Term Effects of Inhaled Ultrafine Particles on Blood Markers of Cardiovascular Diseases: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- The effect of chronic inflammation on female fertility.Reproduction (Cambridge, England) · 2025Review
- Cytotoxic Potencies of Zinc Oxide Nanoforms in A549 and J774 Cells.Nanomaterials (Basel, Switzerland) · 2024Article
- Age and sex differences in the effects of short- and long-term exposure to air pollution on endothelial dysfunction.Environmental health : a global access science source · 2024Article
- Health Endpoint of Exposure to Criteria Air Pollutants in Ambient Air of on a Populated in Ahvaz City, Iran.Frontiers in public health · 2022Article
- Ambient air pollution and inflammatory effects in a Canadian pregnancy cohort.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Association of COVID-19 transmission with high levels of ambient pollutants: Initiation and impact of the inflammatory response on cardiopulmonary disease.The Science of the total environment · 2021Review
- Long-Term Ambient Air Pollution Exposures and Circulating and Stimulated Inflammatory Mediators in a Cohort of Midlife Adults.Environmental health perspectives · 2021Article
- Air Pollution-Induced Autonomic Modulation.Physiology (Bethesda, Md.) · 2020Review
- Cardiovascular adaptations to particle inhalation exposure: molecular mechanisms of the toxicology.American journal of physiology. Heart and circulatory physiology · 2020Review
- Omics for Nurse Scientists Conducting Environmental Health Research.Annual review of nursing research · 2019Article
- Alterations of IL-1beta and TNF-alpha expression in RAW264.7 cell damage induced by two samples of PMScience progressArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThere is a paucity of mechanistic information that is central to the understanding of the adverse health effects of source emission exposures. To identify source emission-related effects, blood and saliva samples from healthy volunteers who spent five days near a steel plant (Bayview site, with and without a mask that filtered many criteria pollutants) and at a well-removed College site were tested for oxidative stress, inflammation and endothelial dysfunction markers.
methodsBiomarker analyses were done using multiplexed protein-array, HPLC-Fluorescence, EIA and ELISA methods. Mixed effects models were used to test for associations between exposure, biological markers and physiological outcomes. Heat map with hierarchical clustering and Ingenuity Pathway Analysis (IPA) were used for mechanistic analyses.
resultsMean CO, SO
conclusionsThese findings suggest that air pollutants in the proximity of steel mill site can influence inflammatory and vascular mechanisms. Use of mask and multiple biomarker data can be valuable in gaining insight into source emission-related health impacts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.