Evidence map›Paper›PMID 30096926›Full record

ArticleInternational journal of molecular sciences2018

Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase.

Weiguang Wang, Joseph I Shapiro

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Weiguang WangThe Joan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Drive, Suite 3408, Huntington, WV 25701, USA. wang68@marshall.edu.
Joseph I ShapiroThe Joan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Drive, Suite 3408, Huntington, WV 25701, USA. shapiroj@marshall.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the signaling function of Na/K-ATPase has been studied for decades, the chasm between the pumping function and the signaling function of Na/K-ATPase is still an open issue. This article explores the relationship between ion pumping and signaling with attention to the amplification of oxidants through this signaling function. We specifically consider the Na/K-ATPase with respect to its signaling function as a superposition of different states described for its pumping function. We then examine how alterations in the relative amounts of these states could alter signaling through the Src-EGFR-ROS pathway. Using assumptions based on some experimental observations published by our laboratories and others, we develop some predictions regarding cellular oxidant stress.

Indexed as

AgingErbB ReceptorsHumansIon PumpsMAP Kinase Signaling SystemMarkov ChainsModels, TheoreticalOuabainOxidative StressReactive Oxygen SpeciesSignal TransductionSodium-Potassium-Exchanging ATPasesrc-Family KinasesEGFR protein, humanErbB ReceptorsIon PumpsOuabainReactive Oxygen SpeciesSodium-Potassium-Exchanging ATPasesrc-Family KinasesagingMarkov chainmaster equationNa/K-ATPaseoxidant stressreactive oxygen speciesSrc

Identifiers

PMID30096926
PMCPMC6121303

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.