Evidence map›Paper›PMID 30096880›Full record

ArticleViruses2018

Neutralizing Epitopes and Residues Mediating the Potential Antigenic Drift of the Hemagglutinin-Esterase Protein of Influenza C Virus.

Yoko Matsuzaki, Kanetsu Sugawara, Yuki Furuse, Yoshitaka Shimotai, Seiji Hongo, Katsumi Mizuta, Hidekazu Nishimura

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Influenza C virus in humans and animals.Clinical and experimental vaccine research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Yoko MatsuzakiDepartment of Infectious Diseases, Yamagata University Faculty of Medicine, Yamagata 990-9585, Japan. matuzaki@med.id.yamagata-u.ac.jp.
Kanetsu SugawaraDepartment of Infectious Diseases, Yamagata University Faculty of Medicine, Yamagata 990-9585, Japan. ksugawar@med.id.yamagata-u.ac.jp.
Yuki FuruseInstitute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan. furusey.tohoku@gmail.com.
Yoshitaka ShimotaiDepartment of Infectious Diseases, Yamagata University Faculty of Medicine, Yamagata 990-9585, Japan. yoshimo@med.id.yamagata-u.ac.jp.
Seiji HongoDepartment of Infectious Diseases, Yamagata University Faculty of Medicine, Yamagata 990-9585, Japan. shongou@med.id.yamagata-u.ac.jp.
Katsumi MizutaDepartment of Microbiology, Yamagata Prefectural Institute of Public Health, Yamagata 990-0031, Japan. mizutak@pref.yamagata.jp.
Hidekazu NishimuraVirus Research Center, Clinical Research Division, Sendai Medical Center, Sendai 983-8520, Japan. hide-nishimura@mte.biglobe.ne.jp.
Yamagata University · JPKyoto University · JPSendai Medical Center · JPYamagata Prefectural Institute of Public Health · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We mapped the hemagglutinin-esterase (HE) antigenic epitopes of the influenza C virus on the three-dimensional (3D) structure of the HE glycoprotein using 246 escape mutants that were selected by a panel of nine anti-HE monoclonal antibodies (MAbs), including seven of the C/Ann Arbor/1/50 virus and two of the C/Yamagata/15/2004 virus. The frequency of variant selection in the presence of anti-HE MAbs was very low, with frequencies ranging from 10

Indexed as

Antigenic VariationAmino Acid SubstitutionAnimalsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralAntigens, ViralBinding SitesEpitopesGammainfluenzavirusHemagglutination Inhibition TestsHemagglutinins, ViralMiceMice, Inbred BALB CMutationViral Fusion ProteinsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralAntigens, ViralEpitopeshemagglutinin esteraseHemagglutinins, ViralViral Fusion Proteinsantigenic structureepidemiologyescape mutantinfluenza C virus

Identifiers

PMID30096880
PMCPMC6116000
OpenAlexW2886618560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.