Evidence map›Paper›PMID 30096879›Full record

ArticleInternational journal of environmental research and public health2018

Sanger and Next Generation Sequencing Approaches to Evaluate HIV-1 Virus in Blood Compartments.

Andrea Arias, Pablo López, Raphael Sánchez, Yasuhiro Yamamura, Vanessa Rivera-Amill

Abstract read
In one paragraph

Article in International journal of environmental research and public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
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  6. Integrase strand transfer inhibitors resistance-associated mutations in HIV-infected pregnant women.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024
    Article
  7. Review
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  15. Review
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  20. Reverse transcriptase and protease inhibitors mutational viral load in HIV infected pregnant women with transmitted drug resistance in Argentina.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrea AriasAIDS Research Infrastructure Program, Ponce Health Sciences University-Ponce Research Institute, Puerto Rico 00716-2348, USA. aarias@psm.edu.
Pablo LópezAIDS Research Infrastructure Program, Ponce Health Sciences University-Ponce Research Institute, Puerto Rico 00716-2348, USA. plopez@psm.edu.
Raphael SánchezAIDS Research Infrastructure Program, Ponce Health Sciences University-Ponce Research Institute, Puerto Rico 00716-2348, USA. rsanchez@psm.edu.
Yasuhiro YamamuraAIDS Research Infrastructure Program, Ponce Health Sciences University-Ponce Research Institute, Puerto Rico 00716-2348, USA. bonyamam@gmail.com.
Vanessa Rivera-AmillAIDS Research Infrastructure Program, Ponce Health Sciences University-Ponce Research Institute, Puerto Rico 00716-2348, USA. vrivera@psm.edu.ORCID 0000-0003-4810-0871

Funding

VIRAL SEQUENCES IN PEDIATRIC HIV INFECTION IN PRG12MD007579 · NIMHD · PONCE SCHOOL OF MEDICINE · PI TORRES-RUIZ, JOSE A · 2012 to 2018
$15.9M
NIMHD NIH HHS G12 MD007579
6 · The paper itself

Abstract

The implementation of antiretroviral treatment combined with the monitoring of drug resistance mutations improves the quality of life of HIV-1 positive patients. The drug resistance mutation patterns and viral genotypes are currently analyzed by DNA sequencing of the virus in the plasma of patients. However, the virus compartmentalizes, and different T cell subsets may harbor distinct viral subsets. In this study, we compared the patterns of HIV distribution in cell-free (blood plasma) and cell-associated viruses (peripheral blood mononuclear cells, PBMCs) derived from ART-treated patients by using Sanger sequencing- and Next-Generation sequencing-based HIV assay. CD4⁺CD45RA

Indexed as

High-Throughput Nucleotide SequencingSequence Analysis, DNAAdultDrug Resistance, ViralHIV-1HIV InfectionsHumansLeukocytes, MononuclearMaleMutationblood compartmentHIV-1memory CD4+ T-cellsNext-Generation SequencingPBMCsplasmaSanger Sequencing

Identifiers

PMID30096879
PMCPMC6122037

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.