Evidence map›Paper›PMID 30096863›Full record

ReviewBrain sciences2018

Individualized Immunological Data for Precise Classification of OCD Patients.

Hugues Lamothe, Jean-Marc Baleyte, Pauline Smith, Antoine Pelissolo, Luc Mallet

Abstract readReview
In one paragraph

Review in Brain sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Article
  9. Alterations in the Nervous System and Gut Microbiota afterInternational journal of molecular sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hugues LamotheCentre Hospitalier Intercommunal de Créteil, 94000 Créteil, France. lamothehugues@gmail.com.
Jean-Marc BaleyteCentre Hospitalier Intercommunal de Créteil, 94000 Créteil, France. jean-marc.baleyte@chicreteil.fr.
Pauline SmithInstitut du Cerveau et de la Moelle Epinière, Sorbonne Universités, UPMC Univ Paris 06, CNRS, INSERM, 75013 Paris, France. pauline.hh.smith@gmail.com.
Antoine PelissoloFondation FondaMental, 94000 Créteil, France. a.pelissolo@gmail.com.
Luc MalletInstitut du Cerveau et de la Moelle Epinière, Sorbonne Universités, UPMC Univ Paris 06, CNRS, INSERM, 75013 Paris, France. luc.mallet@inserm.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obsessive⁻compulsive disorder (OCD) affects about 2% of the general population, for which several etiological factors were identified. Important among these is immunological dysfunction. This review aims to show how immunology can inform specific etiological factors, and how distinguishing between these etiologies is important from a personalized treatment perspective. We found discrepancies concerning cytokines, raising the hypothesis of specific immunological etiological factors. Antibody studies support the existence of a potential autoimmune etiological factor. Infections may also provoke OCD symptoms, and therefore, could be considered as specific etiological factors with specific immunological impairments. Finally, we underline the importance of distinguishing between different etiological factors since some specific treatments already exist in the context of immunological factors for the improvement of classic treatments.

Indexed as

cytokinesimmunologyobsessive–compulsive disorderOCDpediatric acute-onset neuropsychiatric syndrome (PANS)pediatric autoimmune neuropsychological disorders associated with streptococcal infection (PANDAS)psychiatryStreptococcus pyogenesTourette syndromeToxoplasma gondii

Identifiers

PMID30096863
PMCPMC6119917

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.