Evidence map›Paper›PMID 30096859›Full record

ArticleInternational journal of molecular sciences2018

Large-Scale Functional Analysis of CRP-Mediated Feed-Forward Loops.

Chi-Dung Yang, Hsi-Yuan Huang, Sirjana Shrestha, Yen-Hua Chen, Hsien-Da Huang, Ching-Ping Tseng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 3 countries.

Chi-Dung YangInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu 300, Taiwan. chidung1212@gmail.com.
Hsi-Yuan HuangInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu 300, Taiwan. aliken.bi93g@nctu.edu.tw.
Sirjana ShresthaInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu 300, Taiwan. sirju10@yahoo.co.in.
Yen-Hua ChenDepartment of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA. w0a0csnark@gmail.com.ORCID 0000-0002-5794-3769
Hsien-Da HuangInstitute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu 300, Taiwan. bryan@mail.nctu.edu.tw.ORCID 0000-0003-2857-7023
Ching-Ping TsengDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu 300, Taiwan. cpts@cc.nctu.edu.tw.
National Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Feed-forward loops (FFLs) represent an important and basic network motif to understand specific biological functions. Cyclic-AMP (cAMP) receptor protein (CRP), a transcription factor (TF), mediates catabolite repression and regulates more than 400 genes in response to changes in intracellular concentrations of cAMP in

Indexed as

Transcription, GeneticCyclic AMPCyclic AMP Receptor ProteinEscherichia coliGene DosageGene Expression Regulation, BacterialGene OntologyGene Regulatory NetworksGenome, BacterialMicroRNAsMolecular Sequence AnnotationProtein Array AnalysisCyclic AMPCyclic AMP Receptor ProteinMicroRNAscAMP receptor protein (CRP)feed-forward loop (FFL)transcription factor (TF)

Identifiers

PMID30096859
PMCPMC6121374
OpenAlexW2887900109

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.