Evidence map›Paper›PMID 30096798›Full record

ArticleInternational journal of molecular sciences2018

Sonic Hedgehog Medulloblastoma Cancer Stem Cells Mirnome and Transcriptome Highlight Novel Functional Networks.

Agnese Po, Luana Abballe, Claudia Sabato, Francesca Gianno, Martina Chiacchiarini, Giuseppina Catanzaro, Enrico De Smaele, Felice Giangaspero, Elisabetta Ferretti, Evelina Miele and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Re-Sensitizing Cancer Stem Cells to Conventional Chemotherapy Agents.International journal of molecular sciences · 2023
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. The Non-coding Side of Medulloblastoma.Frontiers in cell and developmental biology · 2020
    Review
  9. Article
  10. Article
  11. Integrative cancer therapies
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Agnese PoDepartment of Molecular Medicine, Sapienza University, 00161 Rome, Italy. agnese.po@uniroma1.it.ORCID 0000-0002-9346-8782
Luana AbballeDepartment of Experimental Medicine, Sapienza University, 00161 Rome, Italy. luana.abballe@uniroma1.it.ORCID 0000-0003-4446-2293
Claudia SabatoDepartment of Molecular Medicine, Sapienza University, 00161 Rome, Italy. claudia.sabato@uniroma1.it.ORCID 0000-0001-7533-4660
Francesca GiannoDepartment of Radiological, Oncological and Pathological Science, Sapienza University, 00161 Rome, Italy. francesca.gianno@uniroma1.it.ORCID 0000-0002-6223-9952
Martina ChiacchiariniDepartment of Molecular Medicine, Sapienza University, 00161 Rome, Italy. martina.chiacchiarini@uniroma1.it.ORCID 0000-0001-9229-0372
Giuseppina CatanzaroDepartment of Experimental Medicine, Sapienza University, 00161 Rome, Italy. giuseppina.catanzaro@uniroma1.it.ORCID 0000-0001-8427-9691
Enrico De SmaeleDepartment of Experimental Medicine, Sapienza University, 00161 Rome, Italy. enrico.desmaele@uniroma1.it.ORCID 0000-0003-4524-4423
Felice GiangasperoDepartment of Radiological, Oncological and Pathological Science, Sapienza University, 00161 Rome, Italy. felice.giangaspero@uniroma1.it.ORCID 0000-0001-5382-2380
Elisabetta FerrettiDepartment of Experimental Medicine, Sapienza University, 00161 Rome, Italy. elisabetta.ferretti@uniroma1.it.ORCID 0000-0001-7265-6429
Evelina MieleCenter for Life Nano Science@Sapienza, Istituto Itialiano di Tecnologia, 00161 Rome, Italy. evelina.miele@opbg.net.ORCID 0000-0002-4747-1032
Zein Mersini BesharatDepartment of Experimental Medicine, Sapienza University, 00161 Rome, Italy. zeinmersini.besharat@uniroma1.it.ORCID 0000-0003-0317-9854
Sapienza University of Rome · ITIstituto Neurologico Mediterraneo · ITBambino Gesù Children's Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular classification has improved the knowledge of medulloblastoma (MB), the most common malignant brain tumour in children, however current treatments cause severe side effects in patients. Cancer stem cells (CSCs) have been described in MB and represent a sub population characterised by self-renewal and the ability to generate tumour cells, thus representing the reservoir of the tumour. To investigate molecular pathways that characterise this sub population, we isolated CSCs from Sonic Hedgehog Medulloblastoma (SHH MB) arisen in Patched 1 (

Indexed as

AnimalsCell Line, TumorGene Expression Regulation, NeoplasticHedgehog ProteinsHumansMedulloblastomaMiceMicroRNAsNeoplastic Stem CellsNeural Stem CellsPatched-1 ReceptorPhosphatidylinositol 3-KinasesSignal TransductionTranscriptomeHedgehog ProteinsMicroRNAsPatched-1 ReceptorPhosphatidylinositol 3-KinasesPtch1 protein, mousecancer stem cellsmedulloblastomamicroRNAsRNA-sequencingSonic Hedgehog pathway

Identifiers

PMID30096798
PMCPMC6121264
OpenAlexW2885442253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.