Evidence map›Paper›PMID 30096441›Full record

Trial reportJournal of pain and symptom management2018

An Automated Intervention Did Not Improve Adherence to Oral Oncolytic Agents While Managing Symptoms: Results From a Two-Arm Randomized Controlled Trial.

Alla Sikorskii, Charles W Given, Barbara A Given, Eric Vachon, John C Krauss, Margaret Rosenzweig, Ruth McCorkle, Victoria L Champion, Asish Banik, Atreyee Majumder

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of pain and symptom management, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Effectiveness of mHealth apps on adherence and symptoms to oral anticancer medications: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
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  6. A sequential multiple assignment randomized trial of symptom management for cancer survivors during treatment and their informal caregivers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
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  9. Patient Engagement With an Automated Telephone Symptom Management Intervention: Predictors and Outcomes.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2020
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alla SikorskiiMichigan State University, East Lansing, Michigan, USA.
Charles W GivenMichigan State University, East Lansing, Michigan, USA. Electronic address: givenc@msu.edu.
Barbara A GivenMichigan State University, East Lansing, Michigan, USA.
Eric VachonMichigan State University, East Lansing, Michigan, USA.
John C KraussUniversity of Michigan, Ann Arbor, Michigan, USA.
Margaret RosenzweigUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ruth McCorkleYale University, Orange, Connecticut, USA.
Victoria L ChampionIndiana University, Indianapolis, Indiana, USA.
Asish BanikMichigan State University, East Lansing, Michigan, USA.
Atreyee MajumderMichigan State University, East Lansing, Michigan, USA.

Funding

Improving Adherence to Oral Cancer Agents and Self Care of Symptoms Using an IVRR01CA162401 · NCI · MICHIGAN STATE UNIVERSITY · PI GIVEN, BARBARA ANN, GIVEN, CHARLES W · 2013 to 2016
$2.3M
NCI NIH HHS R01 CA162401
6 · The paper itself

Abstract

contextAn increasing number of oral cancer treatments require patient adherence and symptom self-management.

objectivesThe report presents the effects of a medication reminder and symptom management intervention directed at patients initiating new oral oncolytic agents.

methodsPatients (N = 272) were recruited at six comprehensive cancer centers, interviewed over the telephone after oral agent initiation, and randomized to either standard care or a medication reminder and symptom management intervention. In the intervention arm, the automated system called patients daily to remind them about taking their medications and weekly to assess 18 symptoms and refer patients to a printed Medication Management and Symptom Management Toolkit. Severity of 18 symptoms was also assessed during telephone interviews at Week 4 (midintervention), Week 8 (postintervention), and Week 12 (follow-up). Adherence was measured using the relative dose intensity, the ratio of dose taken by patient out of dose prescribed by the oncologist, and assessed using pill counts at Weeks 4, 8, and 12 and prescribing information from medical records.

resultsThe relative dose intensity was high and did not differ by trial arm. Symptom severity was significantly lower (P < 0.01) in the experimental arm at Week 8 but not at Weeks 4 or 12.

conclusionAdherence may be less of a problem than originally anticipated, and intervention was not efficacious possibly because of already high rates of patient adherence to oral oncolytic medication during first 12 weeks. Longer follow-up in future research may identify subgroups of patients who need interventions to sustain adherence.

Indexed as

Medication AdherenceReminder SystemsAdministration, OralAntineoplastic AgentsAutomationFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasmsSelf-ManagementTelephoneTreatment OutcomeAntineoplastic AgentsadherenceCanceroral agentssymptom management

Identifiers

PMID30096441
PMCPMC7646373

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.