Evidence map›Paper›PMID 30096291›Full record

Trial reportExperimental parasitology2018

Distinguishing neurocysticercosis epilepsy from epilepsy of unknown etiology using a minimal serum mass profiling platform.

Jay S Hanas, James R Hocker, Govindan Ramajayam, Vasudevan Prabhakaran, Vedantam Rajshekhar, Anna Oommen, Josephine J Manoj, Michael P Anderson, Douglas A Drevets, Hélène Carabin

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Experimental parasitology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Jay S HanasDept. of Biochemistry, University of Oklahoma Health Sciences Center (HSC), Oklahoma City, 73104, USA.
James R HockerDept. of Biochemistry, University of Oklahoma Health Sciences Center (HSC), Oklahoma City, 73104, USA.
Govindan RamajayamDept. of Neurological Sciences, Christian Medical College, Vellore, 632004, India.
Vasudevan PrabhakaranDept. of Neurological Sciences, Christian Medical College, Vellore, 632004, India.
Vedantam RajshekharDept. of Neurological Sciences, Christian Medical College, Vellore, 632004, India.
Anna OommenDept. of Neurological Sciences, Christian Medical College, Vellore, 632004, India.
Josephine J ManojDept. of Neurological Sciences, Christian Medical College, Vellore, 632004, India.
Michael P AndersonDept. of Biostatistics and Epidemiology, University of Oklahoma HSC, Oklahoma City, 73104, USA.
Douglas A DrevetsDept. of Internal Medicine, University of Oklahoma HSC, And the VA Medical Center, Oklahoma City, 73104, USA.
Hélène CarabinDept. of Biostatistics and Epidemiology, University of Oklahoma HSC, Oklahoma City, 73104, USA. Electronic address: helene-carabin@ouhsc.edu.
Christian Medical College, Vellore · INUniversity of Oklahoma Health Sciences Center · USOklahoma City University · USUniversity of Oklahoma · USUniversity of Oklahoma Medical Center · US

Funding

Using Host Responses to Neurocysticercosis to Develop Novel, Brain-imaging Free Diagnostics: a US-India PartnershipR01NS098891 · NINDS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CARABIN, HELENE, DREVETS, DOUGLAS ALLEN · 2016 to 2020
$2.6M
Understanding the inflammatory processes of neurocysticercosis: a US-India partneR21NS077466 · NINDS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CARABIN, HELENE · 2011 to 2013
$394k
NINDS NIH HHS R01 NS098891NINDS NIH HHS R21 NS077466
6 · The paper itself

Abstract

Neurocysticercosis is associated with epilepsy in pig-raising communities with poor sanitation. Current internationally recognized diagnostic guidelines for neurocysticercosis rely on brain imaging, a technology that is frequently not available or not accessible in areas endemic for neurocysticercosis. Minimally invasive and low-cost aids for diagnosing neurocysticercosis epilepsy could improve treatment of neurocysticercosis. The goal of this study was to test the extent to which patients with neurocysticercosis epilepsy, epilepsy of unknown etiology, idiopathic headaches and among different types of neurocysticercosis lesions could be distinguished from each other based on serum mass profiling. For this, we collected sera from patients with neurocysticercosis-associated epilepsy, epilepsy of unknown etiology, recovered neurocysticercosis, and idiopathic headaches then performed binary group comparisons among them using electrospray ionization mass spectrometry. A leave one [serum sample] out cross validation procedure was employed to analyze spectral data. Sera from neurocysticercosis patients was distinguished from epilepsy of unknown etiology patients with a p-value of 10

Indexed as

AdolescentAdultAnimalsBrain EdemaDiagnosis, DifferentialEpilepsyFemaleHumansIndiaMaleMiddle AgedNeurocysticercosisSensitivity and SpecificitySpectrometry, Mass, Electrospray IonizationSwineSwine DiseasesDiagnosisElectrospray mass spectrometryEpilepsyIndiaNeurocysticercosisSerum

Identifiers

PMID30096291
PMCPMC6171118
OpenAlexW2885343026

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.