Evidence map›Paper›PMID 30096101›Full record

SynthesisCritical care medicine2018

Laryngeal Injury and Upper Airway Symptoms After Oral Endotracheal Intubation With Mechanical Ventilation During Critical Care: A Systematic Review.

Martin B Brodsky, Matthew J Levy, Erin Jedlanek, Vinciya Pandian, Brendan Blackford, Carrie Price, Gai Cole, Alexander T Hillel, Simon R Best, Lee M Akst

3 registry-linked trialsAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 109 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03726086 completednot on this mapstarted 2019, after this paper: background citation

Post-extubation Assessment of Laryngeal Symptoms and Severity

TypeobservationalSponsorJohns Hopkins UniversityRan2019 to 2023Enrolled365ConditionsIntubation, Intratracheal, Critical Illness, Mechanical Ventilation Complication, Complication of Ventilation TherapyArmslaryngoscopy
NCT05190718 recruitingnot on this mapstarted 2021, after this paper: background citation

Register Study: Implementation of Pharyngeal Electrostimulation Therapy for the Treatment of Acute Neurogenic Dysphagia

Typeobservational_patient_registrySponsorKarl Landsteiner University of Health SciencesRan2021 to 2026Enrolled100ConditionsNeurogenic Dysphagia, Traumatic Brain Injury, Stroke, DysphagiaArmsPharyngeal electrostimulation
NCT06108271 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Innovative Endotracheal Tube Design Reduces Postoperative Laryngeal Injury

TypeinterventionalSponsorUniversity Hospital of the Nuestra Señora de CandelariaRan2023 to 2023Enrolled68ConditionsLaryngeal Injury, Hoarseness, Cough, Sore-throatArmsTriglotix®, Conventional endotracheal tube
3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Identifying the association between post-extubation laryngeal edema and aspiration in acute respiratory failure patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Observational
  15. Article
  16. Intubated COVID-19 Patients More Likely to Develop Subglottic Stenosis.Laryngoscope investigative otolaryngology · 2026
    Article
  17. Article
  18. Observational
  19. Article
  20. Article

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Martin B BrodskyDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD.
Matthew J LevyDepartment of Emergency Medicine, Johns Hopkins University, Baltimore, MD.
Erin JedlanekDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD.
Vinciya PandianOutcomes After Critical Illness and Surgery (OACIS) Research Group, Johns Hopkins University, Baltimore, MD.
Brendan BlackfordDepartment of Medicine, Johns Hopkins University, Baltimore, MD.
Carrie PriceWelch Medical Library, Johns Hopkins University, Baltimore, MD.
Gai ColeDepartment of Emergency Medicine, Johns Hopkins University, Baltimore, MD.
Alexander T HillelDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD.
Simon R BestDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD.
Lee M AkstDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD.

Funding

Understanding and Improving Dysphagia after Mechanical VentilationK23DC013569 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI BRODSKY, MARTIN BRUCE · 2014 to 2017
$836k
NIDCD NIH HHS K23 DC013569
6 · The paper itself

Abstract

objectivesTo systematically review the symptoms and types of laryngeal injuries resulting from endotracheal intubation in mechanically ventilated patients in the ICU. DATA SOURCES: PubMed, Embase, CINAHL, and Cochrane Library from database inception to September 2017. STUDY SELECTION: Studies of adult patients who were endotracheally intubated with mechanical ventilation in the ICU and completed postextubation laryngeal examinations with either direct or indirect visualization. DATA EXTRACTION: Independent, double-data extraction and risk of bias assessment followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Risk of bias assessment followed the Cochrane Collaboration's criteria. DATA SYNTHESIS: Nine studies (seven cohorts, two cross-sectional) representing 775 patients met eligibility criteria. The mean (SD; 95% CI) duration of intubation was 8.2 days (6.0 d; 7.7-8.7 d). A high prevalence (83%) of laryngeal injury was found. Many of these were mild injuries, although moderate to severe injuries occurred in 13-31% of patients across studies. The most frequently occurring clinical symptoms reported post extubation were dysphonia (76%), pain (76%), hoarseness (63%), and dysphagia (49%) across studies.

conclusionsLaryngeal injury from intubation is common in the ICU setting. Guidelines for laryngeal assessment and postextubation surveillance do not exist. A systematic approach to more robust investigations could increase knowledge of the association between particular injuries and corresponding functional impairments, improving understanding of both time course and prognosis for resolution of injury. Our findings identify targets for future research and highlight the long-known, but understudied, clinical outcomes from endotracheal intubation with mechanical ventilation in ICU.

Indexed as

Critical CareHumansIntensive Care UnitsIntubation, IntratrachealLarynxPrevalenceRespiration, ArtificialTrauma Severity Indices

Identifiers

PMID30096101
PMCPMC7219530

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.