ArticleMedicine2018
Predictive markers of depression in hypertension.
Article in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Epidemiology of depressive disorders in people living with hypertension in Africa: a systematic review and meta-analysis.BMJ open · 2020Pooled it
- Feasibility and acceptability of an integrated mind-body intervention for depression: whole-body hyperthermia (WBH) and cognitive behavioral therapy (CBT).International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2024Trial
- Reflex vasodilation and sweating in response to passive whole body heating are blunted in women with major depressive disorder.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- A Polygonatum-Based Functional Formula Improves Stress-Induced Depressive-like Behaviors via Modulation of Neuroinflammation and Tryptophan Metabolism.Foods (Basel, Switzerland) · 2026Article
- Aging, Economic Hardship, and Depression Among Ethnic Groups in Bangladesh: A Cross-Sectional Study.Health science reports · 2026Article
- Interaction between sleep disorder and depression on early onset hypertension: a machine learning modelling approach.Archives of public health = Archives belges de sante publique · 2025Article
- Interaction Effects of Diabetes and Depression on Hypertension Among US Adults: A Cohort Study.Cureus · 2025Article
- Novel biomarkers of the Framingham risk score in patients with depression: A cross-sectional study.World journal of psychiatry · 2025Article
- Utilizing machine learning algorithms for predicting Anxiety-Depression Comorbidity Syndrome in Gastroenterology Inpatients (ADCS-GI).BMC psychiatry · 2025Article
- Protective effect of Tetrandrine on optic nerve by inhibiting glial activation through NF-κB pathway.Heliyon · 2024Article
- Finding the best predictive model for hypertensive depression in older adults based on machine learning and metabolomics research.Frontiers in psychiatry · 2024Article
- Covid-19 and non-communicable diseases (NCDs) in Africa: a narrative review.African health sciences · 2023Review
- Relationship between depressive disorders and biochemical indicators in adult men and women.BMC psychiatry · 2023Article
- Hypertension, sleep quality, depression, and cognitive function in elderly: A cross-sectional study.Frontiers in aging neuroscience · 2023Article
- Interaction between trouble sleeping and depression on hypertension in the NHANES 2005-2018.BMC public health · 2022Article
- Economic Burden of Depressive Symptoms Conditions among Middle-Aged and Elderly People with Hypertension in China.International journal of environmental research and public health · 2021Article
- Classifying depression using blood biomarkers: A large population study.Journal of psychiatric research · 2021Article
- Increase in Right Temporal Cortex Thickness Is Related to Decline of Overall Cognitive Function in Patients With Hypertension.Frontiers in cardiovascular medicine · 2021Article
- Bidirectional association between blood pressure and depressive symptoms in young and middle-age adults: A cohort study.Epidemiology and psychiatric sciences · 2020Article
- Implementing Artificial Intelligence and Digital Health in Resource-Limited Settings? Top 10 Lessons We Learned in Congenital Heart Defects and Cardiology.Omics : a journal of integrative biology · 2020Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertension and depression, as 2 major public health issues, are closely related. For patients having hypertension, in particular, depression is a risk factor for mortality and jeopardizes their wellbeing. The aim of the study is to apply support vector machine (SVM) learning to blood tests and vital signs to classify patients having hypertension complicated by depression and patients having hypertension alone for the identification of novel markers.Data on patients having both hypertension and depression (n = 147) and patients having hypertension alone (n = 147) were obtained from electronic medical records of admissions containing the records on blood tests and vital signs. Using SVM, we distinguished patients having both hypertension and depression from gender- and age-matched patients having hypertension alone.SVM-based classification achieved 73.5% accuracy by 10-fold cross-validation between patients having both hypertension and depression and those having hypertension alone. Twelve features were selected to compose the optimal feature sets, including body temperature (T), glucose (GLU), creatine kinase (CK), albumin (ALB), hydroxybutyrate dehydrogenase (HBDH), blood urea nitrogen (BUN), uric Acid (UA), creatinine (Crea), cholesterol (TC), total protein (TP), pulse (P), and respiration (R).SVM can be used to distinguish patients having both hypertension and depression from those having hypertension alone. A significant association was identified between depression and blood tests and vital signs. This approach can be helpful for clinical diagnosis of depression, but further studies are needed to verify the role of these candidate markers for depression diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.