ArticleJournal of glaucoma2018
Fluorescein Aqueous Angiography in Live Normal Human Eyes.
Article in Journal of glaucoma, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- Aqueous Angiography-Guided Bent Ab Interno Needle Goniectomy in High Versus Low Aqueous Humor Outflow Regions in Primary Open Angle Glaucoma: A Pilot Randomized Controlled Trial.Journal of glaucoma · 2025Trial
- Comparative Evaluation of Functional Aqueous Humor Outflow in Primary Open Angle Glaucoma Versus Primary Angle Closure Glaucoma Using Aqueous Angiography.Journal of glaucoma · 2026Article
- Machine-Learning-Based Automated Schlemm's Canal Volumetric Segmentation for Optical Coherence Tomography.Chemical & biomedical imaging · 2026Article
- Imaging Canine Post-Trabecular Aqueous Outflow Pathways: Effect of Acute Intraocular Pressure Elevation in Normal Eyes.Veterinary ophthalmology · 2026Article
- Cholinergic Improvement of Low-Flow Segmental Aqueous Humor Outflow in Humans.Ophthalmology science · 2026Article
- Atropine-induced intraocular pressure changes and anterior segment structural parameters in dogs assessed by ultrasound biomicroscopy.Frontiers in veterinary science · 2026Article
- Robotic Optical Coherence Tomography With Expanded Three-Dimensional Field-of-View Using Point-Cloud-Based Volumetric Montaging.IEEE transactions on medical imaging · 2025Article
- The aqueous humour dynamics in primary angle closure disease: a computational study.The British journal of ophthalmology · 2025Article
- Robotic Visible-Light Optical Coherence Tomography Visualizes Segmental Schlemm's Canal Anatomy and Segmental Pilocarpine Response.Investigative ophthalmology & visual science · 2025Article
- Aqueous Humor Angiography.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Robotic Visible-Light Optical Coherence Tomography Visualizes Segmental Schlemm's Canal Anatomy and Segmental Pilocarpine Response.bioRxiv : the preprint server for biology · 2024Article
- Reduced Aqueous Humor Outflow Pathway Arborization in Childhood Glaucoma Eyes.Translational vision science & technology · 2024Article
- Comparison of Superior versus Inferior Canaloplasty and Trabeculotomy Using the OMNI Surgical System.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- Segmental Unconventional Outflow in Mouse Eyes.Investigative ophthalmology & visual science · 2023Article
- A fast and fully automated system for glaucoma detection using color fundus photographs.Scientific reports · 2023Article
- First-Generation iStent Bypass Implantation versus ab Externo Canaloplasty Combined with Phacoemulsification in Patients with Primary Open Angle Glaucoma-12-Month Follow-Up.Journal of clinical medicine · 2023Article
- Evaluation of Schlemm's canal with swept-source optical coherence tomography in primary angle-closure disease.BMC ophthalmology · 2023Article
- Differences in Outflow Facility Between Angiographically Identified High- Versus Low-Flow Regions of the Conventional Outflow Pathways in Porcine Eyes.Investigative ophthalmology & visual science · 2023Article
- Advancements in high-resolution imaging of the iridocorneal angle.Frontiers in ophthalmology · 2023Review
- Changes in the deep vasculature assessed using anterior segment OCT angiography following trabecular meshwork targeted minimally invasive glaucoma surgery.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeTo evaluate aqueous humor outflow (AHO) in intact eyes of live human subjects during cataract surgery using fluorescein aqueous angiography.
methodsAqueous angiography was performed in 8 live human subjects (56 to 86 y old; 2 men and 6 women). After anesthesia, fluorescein (2%) was introduced into the eye [either alone or after indocyanine green (ICG; 0.4%)] from a sterile, gravity-driven constant-pressure reservoir. Aqueous angiographic images were obtained with a Spectralis HRA+OCT and FLEX module (Heidelberg Engineering). Using the same device, anterior-segment optical coherence tomography (OCT) and infrared images were also concurrently taken with aqueous angiography.
resultsFluorescein aqueous angiography in the live human eye showed segmental AHO patterns. Initial angiographic signal was seen on average by 14.0±3.0 seconds (mean±SE). Using multimodal imaging, angiographically positive signal colocalized with episcleral veins (infrared imaging) and intrascleral lumens (anterior-segment OCT). Sequential aqueous angiography with ICG followed by fluorescein showed similar segmental angiographic patterns. DISCUSSION: Fluorescein aqueous angiography in live humans was similar to that reported in nonhuman primates and to ICG aqueous angiography in live humans. As segmental patterns with sequential angiography using ICG followed by fluorescein were similar, these tracers can now be used sequentially, before and after trabecular outflow interventions, to assess their effects on AHO in live human subjects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.